Tumor mutation burden, immune checkpoint crosstalk and radiosensitivity in single-cell RNA sequencing data of breast cancer.
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Summary
Differential crosstalk between tumor and immune cells was associated with the patient subtype of breast cancer and could be useful to identify potential biomarker(s) and optimal combination strategies of immune checkpoint blockades and radiation therapy in the management of Breast cancer.
- Type
- article
- Published
- 2019-11-22
- Cited by
- 56
- References
- 48
- OpenAlex
- https://openalex.org/W2990196900
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:208300072
Keywords
Immune checkpoint, Cancer research, Immune system, Radioresistance, Radiosensitivity
References
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Cited by
- Single‐cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy
- A Prognostic Model of 15 Immune-Related Gene Pairs Associated With Tumor Mutation Burden for Hepatocellular Carcinoma
- The current landscape of single-cell transcriptomics for cancer immunotherapy
- New brain metastases after whole-brain radiotherapy of initial brain metastases in breast cancer patients: the significance of molecular subtypes (KROG 16-12)
- A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer
- Building Multi-Dimensional Induced Pluripotent Stem Cells-Based Model Platforms to Assess Cardiotoxicity in Cancer Therapies
- Personalization in Modern Radiation Oncology: Methods, Results and Pitfalls. Personalized Interventions and Breast Cancer
- Immune checkpoint inhibitors: review of the existing evidence and challenges in breast cancer.
- Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis
- Tumor Mutation Burden and Immune Invasion Characteristics in Triple Negative Breast Cancer: Genome High-Throughput Data Analysis
- Single cell RNA sequencing for breast cancer: present and future
- Applications of single-cell sequencing in cancer research: progress and perspectives
- Identifying GNG4 might play an important role in colorectal cancer TMB
- ANXA1 as a Prognostic and Immune Microenvironmental Marker for Gliomas Based on Transcriptomic Analysis and Experimental Validation
- Tumor Microenvironment in Breast Cancer—Updates on Therapeutic Implications and Pathologic Assessment
- Role of tumor mutation burden-related signatures in the prognosis and immune microenvironment of pancreatic ductal adenocarcinoma
- RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples
- Comprehensive Analysis of Glutamate-Rich WD Repeat-Containing Protein 1 and Its Potential Clinical Significance for Pancancer
- Development of Prognostic Model Based on Five-gene Related to Tumor Mutation Burden in Hepatocellular Carcinoma
- High tumor mutational burden predicts worse prognosis for cervical cancer treated with radiotherapy
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