Coactivator condensation at super-enhancers links phase separation and gene control
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Summary
It is postulated that super-enhancers are phase-separated multimolecular assemblies, also known as biomolecular condensates, which provide a means to compartmentalize and concentrate biochemical reactions within cells.
- Type
- article
- Published
- 2018-06-21
- Cited by
- 2,241
- References
- 88
- OpenAlex
- https://openalex.org/W2809057270
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:49356501
Keywords
Coactivator, Enhancer, Transcription (linguistics), Cell biology, Transcription factor
References
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- The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
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- Transcriptional super-enhancers connected to cell identity and disease
- Intrinsic disorder in transcription factors.
- Direct Interaction of RNA Polymerase II and Mediator Required for Transcription in Vivo
- Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes
- Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes
- How eukaryotic transcriptional activators work
- Functional and mechanistic diversity of distal transcription enhancers
- Looping Back to Leap Forward: Transcription Enters a New Era
- Transcription factors: from enhancer binding to developmental control
Cited by
- Nab3’s localization to a nuclear granule in response to nutrient deprivation is determined by its essential prion-like domain
- Dynamics of transcriptional enhancers and chromosome topology in gene regulation
- ERα condensates: chronic stimulation is hard to ignore
- Dynamic chromatin organization in the cell.
- How subtle changes in 3D structure can create large changes in transcription
- Transcription establishes microenvironments that organize euchromatin
- Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
- Concentrating on intrinsic disorder
- Concentrating on intrinsic disorder
- The molecular language of membraneless organelles
- Transient DNA Binding Induces RNA Polymerase II Compartmentalization During Herpesviral Infection Distinct From Phase Separation
- Magnetic Polymer Models for Epigenomic Organisation and Phase Separation
- Dynamic condensates activate transcription
- Chromatin Regulation in Complex Brain Disorders
- Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation
- A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges.
- Who’s in and Who’s Out—Compositional Control of Biomolecular Condensates
- Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer
- Blank spots on the map: some current questions on nuclear organization and genome architecture
- CDK9: a signaling hub for transcriptional control
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