Blank spots on the map: some current questions on nuclear organization and genome architecture
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Summary
Some of the key open areas of investigation in the field of nuclear organization and genome architecture are highlighted with a particular focus on the mechanisms and principles of higher-order genome organization, the emerging role of liquid phase separation in cellular organization, and the functional role of the nuclear lamina in physiological processes.
- Type
- review
- Published
- 2018-09-20
- Cited by
- 23
- References
- 191
- Access
- Open access
- OpenAlex
- https://openalex.org/W2889932197
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52308404
Keywords
Nuclear lamina, Genome, Biology, Genomic organization, Chromatin
References
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- Advanced microscopy methods for visualizing chromatin structure
- Single cell Hi-C reveals cell-to-cell variability in chromosome structure
- Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development
- Partners and post-translational modifications of nuclear lamins
- A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- The radial positioning of chromatin is not inherited through mitosis but is established de novo in early G1.
- LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.
- Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
Cited by
- Nucleolar Expression and Chromosomal Associations in Robertsonian Spermatocytes of Mus musculus domesticus
- Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin
- Chromatin research and biological engineering: an evolving relationship poised for new biomedical impacts
- Reorganization of the nuclear compartments involved in transcription and RNA processing in myonuclei of type I spinal muscular atrophy
- Chromatin is the Same in a Relative Way (But You’re Older)
- Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy
- Metabolism, Epigenetics and Causal Inference in Heart Failure
- Attraction of Likenesses: Mechanisms of Self-Association and Compartmentalization of Eukaryotic Chromatin
- Cell cycle dynamics of lamina associated DNA
- Cell organelles as targets of mammalian cadmium toxicity
- Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization
- Cooperation between Caenorhabditis elegans COMPASS and condensin in germline chromatin organization
- Tidying-up the plant nuclear space: domains, functions, and dynamics
- Cell cycle dynamics of lamina‐associated DNA
- Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin
- Genes on Different Strands Mark Boundaries Associated with Co-regulation Domains
- How Chromatin Stiffens Fibroblasts
- 3D genome organization around nuclear speckles drives mRNA splicing efficiency
- 3D chromatin architecture, BRD4, and Mediator have distinct roles in regulating genome-wide transcriptional bursting and gene network
- Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy
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