The molecular language of membraneless organelles
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Summary
An overview of the molecular underpinnings of the formation and regulation of these membraneless organelles are provided and new light on neurodegenerative diseases is shone on.
- Type
- review
- Published
- 2018-07-25
- Cited by
- 564
- References
- 177
- Access
- Open access
- OpenAlex
- https://openalex.org/W2884082692
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:51719472
Keywords
Organelle, Nucleolus, Cell biology, Chemistry, Biophysics
References
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- Direct Visualization of the Co-transcriptional Assembly of a Nuclear Body by Noncoding RNAs
- The mechanisms of PML-nuclear body formation.
- De novo design of synthetic prion domains
- A Size-Exclusion Permeability Barrier and Nucleoporins Characterize a Ciliary Pore Complex that Regulates Transport into Cilia
- Nucleation of nuclear bodies by RNA
- The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation
Cited by
- Biomolecular Chemistry in Liquid Phase Separated Compartments
- Rigidity Rules in DNA Droplets: Nucleic Acid Flexibility Affects Model Membraneless Organelles.
- Retromer in Synaptic Function and Pathology
- 3' UTRs in the Eye of the TIGER.
- Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation
- Molecular Crowding Tunes Material States of Ribonucleoprotein Condensates
- More than just a phase: the search for membraneless organelles in the bacterial cytoplasm
- Therapeutic dissolution of aberrant phases by nuclear-import receptors
- Mapping viscosity in discrete subcellular locations with a BODIPY based fluorescent probe
- Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics
- Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
- Human antiviral protein MxA forms novel metastable membrane-less cytoplasmic condensates exhibiting rapid reversible “crowding”-driven phase transitions
- Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease
- Biomolecular condensates in cancer cell biology: interleukin-6-induced cytoplasmic and nuclear STAT3/PY-STAT3 condensates in hepatoma cells
- Phase separation of RNA-binding proteins in physiology and disease: An introduction to the JBC Reviews thematic series
- Altered dynamics may drift pathological fibrillization in membraneless organelles
- Peculiarities of the molecular composition of heterochromatin associated with pronucleoli in mouse embryos
- The C-terminal low-complexity domain involved in liquid–liquid phase separation is required for BRD4 function in vivo
- Liquid–liquid phase separation of tau protein: The crucial role of electrostatic interactions
- The challenges of purely mechanistic models in biology and the minimum need for a 'mechanism-plus-X' framework
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