Substrate specificity of human MCPIP1 endoribonuclease
Explore this paper's citation graph
Summary
The studies revealed cleavage sites present in the stem-loops derived from the 3′ untranslated region of the interleukin-6 transcript and induced endonuclease cleavage at the loop motif of stem-loop structures, providing insight into the mechanism of MCPIP1 substrate recognition and its affinity towards various oligonucleotides.
- Type
- article
- Published
- 2018-05-09
- Cited by
- 36
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2807325519
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13664416
Keywords
Endoribonuclease, RNA, Ribonuclease, Stem-loop, Oligonucleotide
References
- Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA
- Interleukin‐1‐inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL‐1β mRNA
- Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
- Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells.
- Protein stabilization by urea and guanidine hydrochloride.
- A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease
- Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
- Engineered proteins with PUF scaffold to manipulate RNA metabolism
- PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA.
- Endonucleolytic RNA cleavage by a eukaryotic exosome
- MCPIP1 Down-Regulates IL-2 Expression through an ARE-Independent Pathway
- Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species.
- The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1
- Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.
- Endonuclease V cleaves at inosines in RNA
- MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation.
- Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation
- Distant Structural Homology Leads to the Functional Characterization of an Archaeal PIN Domain as an Exonuclease*
- VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA
- Vienna RNA secondary structure server
Cited by
- Structural conservation of the PIN domain active site across all domains of life
- Binding specificities of human RNA binding proteins towards structured and linear RNA sequences
- mRNA structure regulates protein expression through changes in functional half-life
- ZC3H12B/MCPIP2, a new active member of the ZC3H12 family
- Involvement of PIN‐like domain nucleases in tRNA processing and translation regulation
- Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response
- Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs
- Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation
- Activity of MCPIP1 RNase in tumor associated processes
- Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
- Structural basis for the recognition of transiently structured AU-rich elements by Roquin
- MCPIP1 ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells
- MCPIP1 RNase and Its Multifaceted Role
- Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy
- MCPIP1 reduces HBV-RNA by targeting its epsilon structure
- MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils
- Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation
- Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection.
- PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases
- Sequence determinants as key regulators in gene expression of T cells
Related papers
- The mechanisms of action of E. coli endonuclease III and T4 UV endonuclease (endonuclease V) at AP sites.
- A Cell-Free System for Investigating Human MARF1 Endonuclease Activity.
- An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA+.
- RNase L, a (2'-5')-oligoadenylate-dependent endoribonuclease: assays and purification of the enzyme; cross-linking to a (2'-5')-oligoadenylate derivative.
- A novel nucleotide excision repair for the conversion of an A/G mismatch to C/G base pair in E. coli.
- Base mismatch-specific endonuclease activity in extracts from Saccharomyces cerevisiae.
- Structure subtraction as an approach to investigation of the mechanism of restriction enzyme action
- [Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity].
- The role of modifications in oligonucleotides in sequence recognition by MvaI restriction endonuclease.
- The structural basis of damaged DNA recognition and endonucleolytic cleavage for very short patch repair endonuclease.