Systems Immunology: Learning the Rules of the Immune System
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Summary
This work focuses on how natural variation is used to find patterns, infer principles, and develop predictive models for two areas: (a) immune cell activation—how single-cell profiling boosts the authors' ability to discover immune cell types and states—and (b) antigen presentation and recognition.
- Type
- review
- Published
- 2018-04-20
- Cited by
- 82
- References
- 247
- Access
- Open access
- OpenAlex
- https://openalex.org/W2800666856
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5027578
Keywords
Biology, Immune system, Major histocompatibility complex, Acquired immune system, Antigen presentation
References
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- Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
- Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility
- Splicing of Distant Peptide Fragments Occurs in the Proteasome by Transpeptidation and Produces the Spliced Antigenic Peptide Derived from Fibroblast Growth Factor-5
- A kinetic model of vertebrate 20S proteasome accounting for the generation of major proteolytic fragments from oligomeric peptide substrates.
- Properties of MHC Class I Presented Peptides That Enhance Immunogenicity
- High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin
- Variation in the human immune system is largely driven by non-heritable influences
- Linking T-cell receptor sequence to functional phenotype at the single-cell level
Cited by
- Reconstructing B-cell receptor sequences from short-read single-cell RNA sequencing with BRAPeS
- Dissecting heterogeneous cell-populations across signaling and disease conditions with PopAlign
- Systems immunology of human humoral immunity
- The variations of TRBV genes usages in the peripheral blood of a healthy population are associated with their evolution and single nucleotide polymorphisms.
- Systems immunology: Integrating multi-omics data to infer regulatory networks and hidden drivers of immunity
- Understanding Adaptive Immune System as Reinforcement Learning
- Immunometabolism: A new target for improving cancer immunotherapy
- Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs
- Antimicrobial and Immunomodulatory Properties and Applications of Marine-Derived Proteins and Peptides
- A Review of Medicinal Properties of some Asteraceae Family Plants on Immune System
- Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases
- Quorum Sensing by Monocyte-Derived Populations
- Next-generation computational tools for interrogating cancer immunity
- Genetic and Epigenetic Regulation of Immune Response and Resistance to Infectious Diseases in Domestic Ruminants.
- Immune stability predicts tuberculosis infection risk in a wild mammal
- Pregnancy Epigenetic Signature in T Helper 17 and T Regulatory Cells in Multiple Sclerosis
- Flow Cytometry Contributions for the Diagnosis and Immunopathological Characterization of Primary Immunodeficiency Diseases With Immune Dysregulation
- Modeling population heterogeneity from microbial communities to immune response in cells
- The Role of Dendritic Cells in Immune Control and Vaccination against γ-Herpesviruses
- Transcriptomic Profiles of Monocyte-Derived Macrophages in Response to Escherichia coli is Associated with the Host Genetics
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