Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
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Summary
The genome sequence of single cells isolated from brain glioblastomas was examined, which revealed shared chromosomal changes but also extensive transcription variation, including genes related to signaling, which represent potential therapeutic targets.
- Type
- article
- Published
- 2014-06-01
- Cited by
- 4,507
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W1792532087
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6627369
Keywords
Biology, Epigenetics, Glioblastoma, Phenotype, Cancer research
References
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- Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Cited by
- Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors
- Single‐cell profiling approaches to probing tumor heterogeneity
- Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome
- Intra‐tumour heterogeneity – going beyond genetics
- Clinical Outcome Prediction Using Single-Cell Data
- Can single-cell RNA sequencing crack the mystery of cells?
- A brief review of single-cell transcriptomic technologies.
- ExpressionDB: An open source platform for distributing genome-scale datasets
- An anatomic transcriptional atlas of human glioblastoma
- scPipe: A flexible R/Bioconductor preprocessing pipeline for single-cell RNA-sequencing data
- A Bayesian model for single cell transcript expression analysis on MERFISH data.
- Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review
- Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches
- 3D genome architecture from populations to single cells.
- The relevance of EMT in breast cancer metastasis: Correlation or causality?
- Molecular Heterogeneity in a Patient-Derived Glioblastoma Xenoline Is Regulated by Different Cancer Stem Cell Populations
- Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma
- Glioblastoma: pathology, molecular mechanisms and markers
- Chromosomal defects track tumor subpopulations and change in progression in oligodendroglioma
- Computational assignment of cell-cycle stage from single-cell transcriptome data.
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