Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer
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Summary
hypermethylation of the HADHB gene was persistently found to be correlated with downregulation of its transcription in colorectal cancer (CRC), and its possible role as a tumor suppressor gene (TSG) was suggested.
- Type
- article
- Published
- 2018-03-02
- Cited by
- 37
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2797420481
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3629894
Keywords
DNA methylation, Epigenetics, Biology, Carcinogenesis, Methylation
References
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- Promoter and histone methylation and p16INK4A gene expression in colon cancer
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- Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.
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- LOSS OF 5-HYDROXYMETHYLCYTOSINE IS AN EPIGENETIC HALLMARK OF MELANOMA
- Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation
- HIGD1A regulates oxygen consumption, ROS production and AMPK activity during glucose deprivation to modulate cell survival and tumor growth
Cited by
- Identification of ACAA1 and HADHB as potential prognostic biomarkers based on a novel fatty acid oxidation-related gene model in head and neck squamous cell carcinoma: A retrospective study.
- Versatile Electroanalytical Bioplatforms for Simultaneous Determination of Cancer-Related DNA 5-Methyl- and 5-Hydroxymethyl-Cytosines at Global and Gene-Specific Levels in Human Serum and Tissues.
- Statistical methods for classification of 5hmC levels based on the Illumina Inifinium HumanMethylation450 (450k) array data, under the paired bisulfite (BS) and oxidative bisulfite (oxBS) treatment
- The mRNA Expression Signature and Prognostic Analysis of Multiple Fatty Acid Metabolic Enzymes in Clear Cell Renal Cell Carcinoma
- Genome-wide methylation and expression profiling identify methylation-associated genes in colorectal cancer.
- DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment
- Comprehensive analysis of 5‐hydroxymethylcytosine in zw10 kinetochore protein as a promising biomarker for screening and diagnosis of early colorectal cancer
- Role of DNA Methylation in the Resistance to Therapy in Solid Tumors
- A comprehensive analysis of the microbiota composition and gene expression in colorectal cancer
- HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
- Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model
- HADHB, a fatty acid beta-oxidation enzyme, is a potential prognostic predictor in malignant lymphoma.
- Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database
- Exploration of Potential Roles of m5C-Related Regulators in Colon Adenocarcinoma Prognosis
- DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer.
- Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects
- Abnormal expression of HADH, an enzyme of fatty acid oxidation, affects tumor development and prognosis
- Multi-Omics Approaches in Colorectal Cancer Screening and Diagnosis, Recent Updates and Future Perspectives
- Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta gene as a tumour suppressor in stomach adenocarcinoma
- CpG Site-Based Signature Predicts Survival of Colorectal Cancer
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