Genomic distribution and possible functions of DNA hydroxymethylation in the brain.
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Summary
How recent advances have improved the understanding of the possible biological roles of 5mC and TET proteins in the brain is discussed, including the genome-wide approach to map 5hmC in different genomic contexts, the gene knockout/knockdown approach to elucidate the functions of TET protein and 5hmCs, and the biochemical approach to uncover potential 5hm C readers.
- Type
- review
- Published
- 2014-11-01
- Cited by
- 98
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2024613932
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40778255
Keywords
5-Methylcytosine, 5-Hydroxymethylcytosine, Biology, DNA methylation, Epigenetics
References
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- Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state
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- DNA methylation and Memory Formation
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- Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
Cited by
- Altersabhängige Level von 5-Methyl-, 5-Hydroxymethyl- und 5-Formylcytosin in Hirngeweben des Menschen und der Maus†
- The influence of DNA methylation on gene expression involved in the etiology and treatment of psychiatric disorders
- Methylation as an epigenetic source of random genetic effects in the classical twin design
- The Effect of Trichloroethylene on Adverse Birth Outcomes.
- Decoding the non‐coding genome: elucidating genetic risk outside the coding genome
- Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
- Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio)
- Micro‐RNAs meet epigenetics to make for better brains
- Enzymatic DNA oxidation: mechanisms and biological significance
- DNA 5-hydroxymethylation in human adipose tissue differs between subcutaneous and visceral adipose tissue depots.
- Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder
- Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues
- H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase
- Effects of cancer therapies on the brain : from molecular mechanisms to behavioral outcomes
- Understanding the genetic liability to schizophrenia through the neuroepigenome
- High-Sensitivity and High-Efficiency Detection of DNA Hydroxymethylation in Genomic DNA by Multiplexing Electrochemical Biosensing.
- Białka TET a modyfikacje epigenetyczne w nowotworach TET proteins and epigenetic modifications in cancers
- Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus
- Hydroxymethylation is uniquely distributed within term placenta, and is associated with gene expression
- Long-term epigenetic alterations in a rat model of Gulf War Illness.
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