DNA methylation-based biomarkers and the epigenetic clock theory of ageing
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Summary
Biomarkers of ageing based on DNA methylation data enable accurate age estimates for any tissue across the entire life course and link developmental and maintenance processes to biological ageing, giving rise to a unified theory of life course.
- Type
- review
- Published
- 2018-04-11
- Cited by
- 2,595
- References
- 167
- OpenAlex
- https://openalex.org/W2796559433
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4709691
Keywords
Epigenetics, Biology, Ageing, DNA methylation, Computational biology
References
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- Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
- Programmed Death Phenomena: From Organelle to Organism
- Accelerated epigenetic aging in Down syndrome
- Cellular senescence and cancer
- Cellular senescence: when bad things happen to good cells
- DNA methylation age of human tissues and cell types
Cited by
- Functional genomic insights into the environmental determinants of mammalian fitness
- PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging
- Exercise, Diet and Sleeping as Regenerative Medicine Adjuvants: Obesity and Ageing as Illustrations
- Senescence of multicellular individuals: imbalance of epigenetic and non-epigenetic information in histone modifications
- Predicting cellular aging following exposure to adversity: Does accumulation, recency, or developmental timing of exposure matter?
- Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study.
- Properties of the epigenetic clock and age acceleration
- Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
- Developmental programming of aging trajectory.
- DNA methylation age – environmental influences, health impacts, and its role in environmental epidemiology
- Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women
- Translational Geroscience: From invertebrate models to companion animal and human interventions
- Epigenetic Clock and Relative Telomere Length Represent Largely Different Aspects of Aging in the Berlin Aging Study II (BASE-II)
- The involvement of human endogenous retroviruses K (HERV-K) in aging processes via induction of inflammation
- Genetic and epigenetic regulation of human aging and longevity
- DNA Methylation Clocks in Aging: Categories, Causes, and Consequences
- Time and the Metrics of Aging
- Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites
- Dynamic DNA methylation: in the right place at the right time
- DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples.
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