Telomere states and cell fates
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Summary
Recent findings are integrated into a new, probabilistic view of the telomere to explain how and when it can signal not only its own fate but also that of a cell.
- Type
- article
- Published
- 2000-11-02
- Cited by
- 1,346
- References
- 49
- OpenAlex
- https://openalex.org/W1579661837
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205010530
Keywords
Telomere, Biology, Ageing, Cellular Aging, Cell biology
References
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- Longevity, stress response, and cancer in aging telomerase-deficient mice.
- A Protein-Counting Mechanism for Telomere Length Regulation in Yeast
- Telomeres shorten during ageing of human fibroblasts
- Specific telomerase RNA residues distant from the template are essential for telomerase function.
- Yeast Ku as a regulator of chromosomal DNA end structure.
- Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
- Telomere length predicts replicative capacity of human fibroblasts.
- Intramitotic variation in proliferative potential: stochastic events in cellular aging.
- Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation.
Cited by
- RNA Interference and Development
- Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.
- A Trypanosoma brucei Protein Complex That Binds G-overhangs and Co-purifies with Telomerase Activity*
- Immunosenescence phenotypes in the telomerase knockout mouse
- Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells.
- The INK4a/ARF locus and human cancer.
- Human melanocyte senescence and melanoma susceptibility genes
- Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span*
- TIN2 Mediates Functions of TRF2 at Human Telomeres*
- Leukocyte telomere length and cardiovascular disease in the cardiovascular health study.
- Analysis of hTERT mRNA expression in biliary tract and pancreatic cancer.
- Low oxygen tension alleviates oxidative damage and delays cellular senescence in G6PD-deficient cells
- A single-stage mechanism controls replicative senescence through Sudden Senescence Syndrome
- Bats and birds: Exceptional longevity despite high metabolic rates.
- The (pro)renin receptor in health and disease
- Imetelstat (GRN163L)--telomerase-based cancer therapy.
- A novel zinc finger protein Zfp637 behaves as a repressive regulator in myogenic cellular differentiation
- Leukocyte telomere length is associated with noninvasively measured age-related disease: The Cardiovascular Health Study.
- Educational Attainment and Late Life Telomere Length in the Health, Aging and Body Composition Study
- Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors.
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