Within-Host Variations of Human Papillomavirus Reveal APOBEC Signature Mutagenesis in the Viral Genome

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Summary

C-to-T transitions, a characteristic change mediated by cellular APOBEC cytosine deaminases, were predominantly detected throughout the whole viral genome, most strikingly in low-grade CIN lesions, suggesting within-host variations of the HPV genome are primarily generated through the interaction with host cell DNA-editing enzymes.

Type
article
Published
2018-03-28
Cited by
49
References
47
Access
Open access

Keywords

Biology, APOBEC, Mutagenesis, Virology, Genome

References

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