Mutational Signatures: The Patterns of Somatic Mutations Hidden in Cancer Genomes
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Summary
The current understanding of mutational patterns and mutational signatures in light of both the somatic cell paradigm of cancer research and the recent developments in the field of cancer genomics is summarized.
- Type
- review
- Published
- 2013-12-29
- Cited by
- 467
- References
- 102
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973702005
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:998994
Keywords
Somatic cell, Biology, Genetics, Genome, Genomics
References
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- MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS
- The landscape of cancer genes and mutational processes in breast cancer
- Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
- Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
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- Whole-genome sequencing identifies new genetic alterations in meningiomas
- Epidemiology and Molecular Biology of Head and Neck Cancer
- Atezolizumab in invasive and metastatic urothelial carcinoma
- Ultraviolet radiation-mediated development of cutaneous melanoma: An update.
- Breast Cancer Heterogeneity in Primary and Metastatic Disease.
- Shared and unique mutational gene co-occurrences in cancers.
- Frailty in Childhood Cancer Survivors
- Stress-Induced Mutation Rates Show a Sigmoidal and Saturable Increase Due to the RpoS Sigma Factor in Escherichia coli
- Stakeholders’ perspectives on biobank-based genomic research: systematic review of the literature
- Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
- Effects of omics data combinations on in silico tumor-normal tissue classification
- Dissecting genetic and environmental mutation signatures with model organisms.
- Pathway-driven discovery of epilepsy genes
- Therapeutic opportunities within the DNA damage response
- Lagging strand replication shapes the mutational landscape of the genome
- Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
- Pathogenesis of hepatocellular carcinoma according to aetiology.
- Design and Analysis of Single-Cell Sequencing Experiments.
- Helping the hypermutator: The Fhit-APOBEC connection
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