Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer’s Disease
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Summary
Recent research contributions that have expanded the understanding of the nature of the translocation of microbiome-derived neurotoxins-across biophysiological barriers are reviewed and the role of molecular neurobiology and mechanistic contribution of polymicrobial infections to AD-type neuropathological change is discussed.
- Type
- article
- Published
- 2018-03-19
- Cited by
- 41
- References
- 90
- Access
- Open access
- OpenAlex
- https://openalex.org/W2794173887
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4568040
Keywords
Downregulation and upregulation, Disease, microRNA, Microbiome, Alzheimer's disease
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Cited by
- The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia
- Role of microRNA (miRNA) and Viroids in Lethal Diseases of Plants and Animals. Potential Contribution to Human Neurodegenerative Disorders
- Rôle des bactéries anaérobies en clinique humaine
- Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture
- microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD)
- Down-Regulation of Essential Synaptic Components by GI-Tract Microbiome-Derived Lipopolysaccharide (LPS) in LPS-Treated Human Neuronal-Glial (HNG) Cells in Primary Culture: Relevance to Alzheimer’s Disease (AD)
- A potential species of next-generation probiotics? The dark and light sides of Bacteroides fragilis in health.
- Atropa belladonna Expresses a microRNA (aba-miRNA-9497) Highly Homologous to Homo sapiens miRNA-378 (hsa-miRNA-378); both miRNAs target the 3′-Untranslated Region (3′-UTR) of the mRNA Encoding the Neurologically Relevant, Zinc-Finger Transcription Factor ZNF-691
- Time to test antibacterial therapy in Alzheimer's disease.
- Lipopolysaccharide-stimulated, NF-kB-, miRNA-146a- and miRNA-155-mediated molecular-genetic communication between the human gastrointestinal tract microbiome and the brain.
- Facilitation of Gastrointestinal (GI) Tract Microbiome-Derived Lipopolysaccharide (LPS) Entry Into Human Neurons by Amyloid Beta-42 (Aβ42) Peptide
- Gastrointestinal (GI) Tract Microbiome-Derived Neurotoxins—Potent Neuro-Inflammatory Signals From the GI Tract via the Systemic Circulation Into the Brain
- Gut Microbiota: Implications in Alzheimer’s Disease
- The roles of the gut microbiota–miRNA interaction in the host pathophysiology
- MicroRNAs as Candidate Biomarkers for Alzheimer’s Disease
- Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
- Modulating host gene expression via gut microbiome–microRNA interplay to treat human diseases
- Circulating microRNA-122, microRNA-126-3p and microRNA-146a are associated with inflammation in patients with pre-diabetes and type 2 diabetes mellitus: A case control study
- miR-146a dysregulates energy metabolism during neuroinflammation
- Gastrointestinal (GI)-Tract Microbiome Derived Neurotoxins and their Potential Contribution to Inflammatory Neurodegeneration in Alzheimer’s Disease (AD)
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