miR-146a dysregulates energy metabolism during neuroinflammation
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Summary
It is demonstrated that the modulation of miR-146a in response to neuroinflammatory stimuli may mediate the loss of mitochondrial integrity and function in cells, thereby contributing to the progression of beta-amyloid and tau pathology in the AD brain.
- Type
- article
- Published
- 2021-05-24
- Cited by
- 34
- References
- 74
- Access
- Open access
- OpenAlex
- https://openalex.org/W3165054375
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:235168679
Keywords
Neuroinflammation, Downregulation and upregulation, Cell biology, microRNA, Biology
References
- Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
- Estrogen amelioration of Aβ-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ERβ, AKAP and Drp1
- Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer's Disease
- MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease
- Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD).
- Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline
- microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF).
- Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions.
- Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
- Amyloid-beta Leads to Impaired Cellular Respiration, Energy Production and Mitochondrial Electron Chain Complex Activities in Human Neuroblastoma Cells
- Regulation of Complement Factor H (CFH) by Multiple miRNAs in Alzheimer’s Disease (AD) Brain
- Loss of Intra- and Inter-Network Resting State Functional Connections with Alzheimer’s Disease Progression
- Complement activation in amyloid plaques in Alzheimer’s dementia
- miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression
- Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses
- Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
- Slow Degradation of Aggregates of the Alzheimer’s Disease Amyloid β-Protein by Microglial Cells*
- Modulation of astrocytic metabolic phenotype by proinflammatory cytokines
- Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer’s Disease
- MitomiRs in human inflamm-aging: a hypothesis involving miR-181a, miR-34a and miR-146a.
Cited by
- A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications
- The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
- Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential
- The role of microRNAs in neurodegenerative diseases: a review
- Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p
- Genetic Polymorphisms in Oxidative Stress and Inflammatory Pathways as Potential Biomarkers in Alzheimer’s Disease and Dementia
- RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology
- Selenium deficiency caused hepatitis in chickens via the miR-138-5p/SelM/ROS/Ca2+ overload pathway induced by hepatocyte necroptosis.
- Biomarkers in neurodegenerative diseases: a broad overview
- REGULATORY ROLES OF microRNAs IN MODULATING MITOCHONDRIAL DYNAMICS, AMYLOID BETA FIBRILLATION, MICROGLIAL ACTIVATION, AND CHOLINERGIC SIGNALING: IMPLICATIONS FOR ALZHEIMER'S DISEASE PATHOGENESIS.
- MiR-146a reduces fibrosis after glaucoma filtration surgery in rats
- Potential Application of MicroRNAs and Some Other Molecular Biomarkers in Alzheimer’s Disease
- Extracellular Vesicles as Mediators of Neuroinflammation in Intercellular and Inter-Organ Crosstalk
- The complex effects of miR-146a in the pathogenesis of Alzheimer’s disease
- The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
- Brain–Periphery Axes: The Potential Role of Extracellular Vesicles-Delivered miRNAs
- Bridging brain and blood: a prospective view on neuroimaging-exosome correlations in HIV-associated neurocognitive disorders
- Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections
- Exploring Non‐Coding RNA Regulation of the Blood–Brain Barrier in Neurodegenerative Diseases: A Systematic Review
- Targeted miRNA Delivery in Epilepsy: Mechanisms, Advances, and Therapeutic Potential
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