microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD)
Explore this paper's citation graph
Summary
Recent studies of a miRNA-34a-up-regulation coupled to SHANK3 mRNA down-regulation in sporadic AD superior-temporal lobe compared to age-matched controls support the hypothesis of an altered mi RNA-mRNA coupled signaling network in AD.
- Type
- article
- Published
- 2019-02-06
- Cited by
- 39
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2914397978
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:59604538
Keywords
microRNA, Biology, Neocortex, Messenger RNA, Neurodegeneration
References
- Analysis of RNA from Alzheimer’s Disease Post-mortem Brain Tissues
- Microglia-Mediated Synapse Loss in Alzheimer's Disease
- Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and APP transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
- The emerging role of SHANK genes in neuropsychiatric disorders
- Alzheimer's disease-related alterations in synaptic density: Neocortex and hippocampus
- The Shank family of scaffold proteins.
- Vertebrate MicroRNA Genes
- miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation.
- Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies.
- Modeling Autism by SHANK Gene Mutations in Mice
- Synaptic proteins and receptors defects in autism spectrum disorders
- Most mammalian mRNAs are conserved targets of microRNAs.
- A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease.
- Quantitative synaptic alterations in the human neocortex during normal aging
- Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
- New roles for “old” microRNAs in nervous system function and disease
- Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.
- Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders.
- Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders
- microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration
Cited by
- Addressing Alzheimer’s disease (AD) neuropathology using anti-microRNA (AM) strategies
- Hypoxia and Inflammation as a Consequence of β-Fibril Accumulation: A Perspective View for New Potential Therapeutic Targets
- Down-Regulation of Essential Synaptic Components by GI-Tract Microbiome-Derived Lipopolysaccharide (LPS) in LPS-Treated Human Neuronal-Glial (HNG) Cells in Primary Culture: Relevance to Alzheimer’s Disease (AD)
- Atropa belladonna Expresses a microRNA (aba-miRNA-9497) Highly Homologous to Homo sapiens miRNA-378 (hsa-miRNA-378); both miRNAs target the 3′-Untranslated Region (3′-UTR) of the mRNA Encoding the Neurologically Relevant, Zinc-Finger Transcription Factor ZNF-691
- MicroRNA-34a Regulates the Depression-like Behavior in Mice by Modulating the Expression of Target Genes in the Dorsal Raphè
- MicroRNA-34a Acutely Regulates Synaptic Efficacy in the Adult Dentate Gyrus In Vivo
- miRNAs-dependent regulation of synapse formation and function
- Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration by Toxoplasma gondii Infection
- Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
- MicroRNAs Regulating Cytoskeleton Dynamics, Endocytosis, and Cell Motility—A Link Between Neurodegeneration and Cancer?
- Predicted Regulatory Pathways for Long Noncoding RNA-SNHG7 via miR-34a and its Targets in Alzheimer’s Disease
- Association of SHANK Family with Neuropsychiatric Disorders: An Update on Genetic and Animal Model Discoveries
- Expression of the Excitatory Postsynaptic Scaffolding Protein, Shank3, in Human Brain: Effect of Age and Alzheimer’s Disease
- Novel microRNA-455-3p mouse models to study Alzheimer’s disease pathogenesis
- Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease
- MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer's disease
- Deregulated mitochondrial microRNAs in Alzheimer’s disease: Focus on synapse and mitochondria
- Astrocytic MicroRNA in Ageing, Inflammation, and Neurodegenerative Disease
- NF-kB (p50/p65)-Mediated Pro-Inflammatory microRNA (miRNA) Signaling in Alzheimer's Disease (AD)
- Biomarkers of Frailty: miRNAs as Common Signatures of Impairment in Cognitive and Physical Domains
Related papers
- Constructing series of clones with different functional regions deletion of PEPV 5′Untranslated region and sequence analysis
- The Effects of ABCB1 3′-Untranslated Region Variants on mRNA Stability
- Sequences near both termini of the C/EBPβ mRNA 3＇ untranslated region are important for its tumor suppression activity
- 食管癌细胞SHEEC中NGAL基因5’—UTR和3’—UTR的克隆与鉴定
- Abundant conserved microRNA target sites in the 5′-untranslated region and coding sequence
- The composition of untranslated regions in Trypanosoma cruzi genes.
- Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells
- Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5'- and 3'-UTRs.
- 5′-UTR and 3′-UTR Regulation of MICB Expression in Human Cancer Cells by Novel microRNAs