Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation
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Summary
Novel mechanistic understanding of metformin in FGSCs is provided by combining histone epigenetics and phenotypic analyses, which highlight the role of the metformin-H2BK5bhb-Gata2 pathway in cell fate determination and regulation.
- Type
- article
- Published
- 2023-05-26
- Cited by
- 9
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W4378189413
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:258892770
Keywords
Stem cell, Germline, Histone, Cell biology, Biology
References
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- Reproductive Biology and Endocrinology
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- Effects of HMG on revascularization and follicular survival in heterotopic autotransplants of mouse ovarian tissue.
- Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome.
- Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review
- Anti-diabetic drug metformin: challenges and perspectives for cancer therapy.
- Production of fat-1 transgenic rats using a post-natal female germline stem cell line.
- Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage
- Assessment of genomic instability in normal and diabetic rats treated with metformin.
- GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.
- Metformin improves healthspan and lifespan in mice
- Production of offspring from a germline stem cell line derived from neonatal ovaries
- Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation
- Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.
- Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
Cited by
- Exploring the presence of female germline stem cells in rats and mice
- Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy
- Cistanche deserticola polysaccharides enhance female germline stem cell differentiation through BMP/SMAD signaling to mitigate premature ovarian failure.
- H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation
- CHIR99021 Enhances the Proliferation of Mouse Female Germline Stem Cells Via Modulating ERCC2
- Lysine β-Hydroxybutyrylation in Metabolic Plasticity and Disease Pathogenesis.
- Global Profiling of Protein β-hydroxybutyrylome in Porcine Liver
- From ketogenic metabolism to targeted therapeutics: current advances in β-hydroxybutyrylation
- Polystyrene nanoplastics disrupt ovarian development via cytoskeletal remodeling and epigenetic reprogramming particularly in granulosa cells.
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