Regulation and Function of the PD-L1 Checkpoint
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Summary
The roles of the PD-1-PD-L1 axis in cancer is reviewed, focusing on recent findings on the mechanisms that regulate PD-L1 expression at the transcriptional, posttranscriptional, and protein level, to inform the design of more precise and effective cancer immune checkpoint therapies.
- Type
- review
- Published
- 2018-03-20
- Cited by
- 1,878
- References
- 231
- Access
- Open access
- OpenAlex
- https://openalex.org/W2790574591
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4084918
Keywords
Biology, Function (biology), Cancer research, Cell biology, Computational biology
References
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Cited by
- Targeting PD-L1 Protein: Translation, Modification and Transport.
- Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma
- LncRNA KRT19P3 Is Involved in Breast Cancer Cell Proliferation, Migration and Invasion
- The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution
- Improved cancer immunotherapy strategies by nanomedicine.
- AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3
- Dynamic human immune and tumour cells cross-talk in PDX-humanised mice warrants checkpoint inhibitor cancer immunotherapies assessment
- Vaccine immunotherapy with ARNAX induces tumor‐specific memory T cells and durable anti‐tumor immunity in mouse models
- Epigenetic regulators of programmed death‐ligand 1 expression in human cancers
- Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy
- Creating molecules that modulate immune responses
- Role of Immunotherapy for Oncogene-Driven Non-Small Cell Lung Cancer
- Myeloid-Derived Suppressor Cells as a Regulator of Immunity in Organ Transplantation
- Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors
- Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells
- Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis
- BDCA1+CD14+ Immunosuppressive Cells in Cancer, a Potential Target?
- [Small interfering RNA-mediated programmed cell death-ligand 1 silencing in human glioma cells enhances human CD8+ T lymphocyte cytotoxicity in vitro].
- Efficacy of PD-1 or PD-L1 inhibitors and PD-L1 expression status in cancer: meta-analysis
- Recent updates on cancer immunotherapy
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