Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells
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Summary
It is shown that PSCs in vitro express higher PD-L1 mRNA and protein levels compared to the levels present in PDAC cells, and that interferon regulatory factor 1 (IRF1) mediates IFN-γ-induced PD- L1 expression in P SCs.
- Type
- article
- Published
- 2018-09-05
- Cited by
- 38
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2888969223
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52160741
Keywords
BRD4, IRF1, Gene knockdown, Cancer research, Hepatic stellate cell
References
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- Selective inhibition of BET bromodomains
- Cancer immunotherapy comes of age
- Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Diminished Survival
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- Nivolumab versus Docetaxel in Advanced Non-squamous Non-small Cell Lung Cancer
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- BET bromodomain inhibition as a therapeutic strategy to target c-Myc
- RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- MT1-MMP cooperates with KrasG12D to promote pancreatic fibrosis through increased TGF-β signaling
Cited by
- BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response
- Stress responses in stromal cells and tumor homeostasis.
- Targeting the tumor microenvironment for pancreatic ductal adenocarcinoma therapy.
- IRF1 inhibits antitumor immunity through the upregulation of PD-L1 in the tumor cell
- Expression and clinical value of PD‐L1 which is regulated by BRD4 in tongue squamous cell carcinoma
- Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
- Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1.
- Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy
- How microRNAs affect the PD-L1 and its synthetic pathway in cancer.
- Targeting the epigenetic regulation of antitumour immunity
- Transcriptional Regulation of Cancer Immune Checkpoints: Emerging Strategies for Immunotherapy
- The BET family in immunity and disease
- Trials and Tribulations of Pancreatic Cancer Immunotherapy
- IRF1 regulates the progression of colorectal cancer via interferon-induced proteins
- The Role of Oncogenes and Redox Signaling in the Regulation of PD-L1 in Cancer
- XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer
- Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer
- A New Trend in Cancer Treatment: The Combination of Epigenetics and Immunotherapy
- Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity
- Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
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