Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Explore this paper's citation graph
Summary
The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
- Type
- review
- Published
- 2017-10-05
- Cited by
- 6,847
- References
- 118
- Access
- Open access
- OpenAlex
- https://openalex.org/W2762087180
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21648473
Keywords
Biology, Nexus (standard), Programmed cell death, Disease, Cell biology
References
- Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis*
- Regional Membrane Phospholipid Alterations in Alzheimer's Disease
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- Membrane Phospholipid Alterations In Alzheimer's Disease: Deficiency of Ethanolamine Plasmalogens
- Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging
- Glutaminolysis and Transferrin Regulate Ferroptosis
- Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
- The preclinical phase of the pathological process underlying sporadic Alzheimer's disease.
- Effect of pioglitazone medication on the incidence of dementia
- Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides.
- Spreading of pathology in neurodegenerative diseases: a focus on human studies
- RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels
- Mammalian Trit1 is a tRNA([Ser]Sec)-isopentenyl transferase required for full selenoprotein expression.
- Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- Ferroptosis: an iron-dependent form of nonapoptotic cell death.
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease
- Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development
Cited by
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
- Iron and Cancer
- Ferroptosis: The Greasy Side of Cell Death.
- Cell–cell contacts protect against t-BuOOH-induced cellular damage and ferroptosis in vitro
- Identification of Ferroptosis-Related Biomarkers for Diagnosis and Molecular Classification of Staphylococcus aureus-Induced Osteomyelitis
- Pore-forming activity and structural autoinhibition of the gasdermin family
- Cell death in drug-induced liver injury.
- Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy.
- The Ferrous Awakens.
- MTD-like motif of a BH3-only protein, BNIP1, induces necrosis accompanied by an intracellular calcium spike.
- Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases
- The Role of NADPH Oxidase and Neutrophil Extracellular Traps in the Pathogenesis of Systemic Lupus Erythematosus
- Activity-based sensing fluorescent probes for iron in biological systems
- Redox regulation of microRNAs in cancer.
- p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
- An Element of Life.
- Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
- 13 reasons why the brain is susceptible to oxidative stress
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- ENPP2 protects cardiomyocytes from erastin-induced ferroptosis.
Related papers
- Methods and Trends for Water-Energy-Carbon Emissions Nexus Assessment
- Research progress on metabolic regulating cell fate
- Thermochemical studies on cell metabolism: Part I. Thermal equations for the metabolism of resting cells
- Microcalorimetric studies on the metabolism of Chlorella vulgaris.
- Mechanisms of cell injury with hepatotoxic chemicals.
- Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells