Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection
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Summary
Co-immunoprecipitation does not identify any detectable molecular interaction between the endogenous α1-ACT and PrP either in the brain homogenates of 263K-infected hamsters or in the lysates of prion- Infected cultured cells.
- Type
- article
- Published
- 2017-09-03
- Cited by
- 9
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2759849433
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25805528
Keywords
Colocalization, Scrapie, Biology, Immunohistochemistry, Microglia
References
- The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins
- The Levels of Tau Isoforms Containing Exon-2 and Exon-10 Segments Increased in the Cerebrospinal Fluids of the Patients with Sporadic Creutzfeldt-Jakob Disease
- Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes.
- Immunohistochemical study of microglia in the Creutzfeldt-Jakob diseased brain
- Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins.
- Scrapie strains maintain biological phenotypes on propagation in a cell line in culture
- Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases
- Global Protein Differential Expression Profiling of Cerebrospinal Fluid Samples Pooled from Chinese Sporadic CJD and non-CJD Patients
- Genetic association between susceptibility to Parkinson's disease and alpha1-antichymotrypsin polymorphism.
- Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins.
- Alpha-1-antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA).
- Inflammatory Markers in Matched Plasma and Cerebrospinal Fluid from Patients with Alzheimer’s Disease
- Elevated Levels of Tau Protein in Cerebrospinal Fluid of Patients With Probable Creutzfeldt-Jakob Disease
- Identification of prion protein binding proteins by combined use of far‐Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry
- Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
- Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin.
- Acute Phase Reactant α1Antichymotrypsin Is Increased in Cerebrospinal Fluid and Serum of Patients with Probable Alzheimer Disease
- Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.
- The Prepared Tau Exon-Specific Antibodies Revealed Distinct Profiles of Tau in CSF of the Patients with Creutzfeldt-Jakob Disease
- Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD
Cited by
- Significant enhanced expressions of aquaporin-1, -4 and -9 in the brains of various prion diseases
- Global profiles of a cetylated proteins in the brains of scrapie agents 139A- and ME7-infected mice collected at mid-early, mid-late and terminal stage
- Association of α-1-antichymotrypsin expression with the development of conformational changes of Tau protein in Alzheimer's disease brain.
- Serpin Signatures in Prion and Alzheimer’s Diseases
- Alpha-1-antichymotrypsin as a novel biomarker for diagnosis, prognosis, and therapy prediction in human diseases
- Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
- Activation of Innate Immunity and Autophagy in Brain Tissues with Prion Disease and Degradation of Abnormal PrPs in Cells — China’s Studies
- Molecules of senescent glial cells differentiate Alzheimer’s disease from ageing
- Accumulation of Prion Triggers the Enhanced Glycolysis via Activation of AMKP Pathway in Prion-Infected Rodent and Cell Models
- Diagnosis in Scrapie: Conventional Methods and New Biomarkers
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