Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
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Summary
The data suggest that IL‐6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.
- Type
- article
- Published
- 1989-01-02
- Cited by
- 923
- References
- 13
- OpenAlex
- https://openalex.org/W2041184642
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41533269
Keywords
Acute-phase protein, Haptoglobin, Transferrin, Serum amyloid A, Albumin
References
- A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1
- Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
- Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures.
- Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
- Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2).
- Discrimination of hepatocyte‐stimulating activity from human recombinant tumor necrosis factor α
- Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.
- Interleukin-1 and the pathogenesis of the acute-phase response.
- Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes
- Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro
- The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes.
- The acute phase response to injury and infection
- A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1.
Cited by
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- The hepatic interleukin‐6 receptor Down‐regulation of the interleukin‐6 binding subunit (gp80) by its ligand
- Human recombinant C5a enhances lipopolysaccharide‐induced synthesis of interleukin‐6 by human monocytes
- Analysis of Graves’ ophthalmopathy patients’ tear protein spectrum
- Microheterogeneity of acute phase proteins in patients with clinically active and clinically nonactive osteoarthritis
- Role for circulating lipoproteins in protection from endotoxin toxicity
- Production of Interleukin‐6 Induced by Hypoxia Linked to Peripheral Arterial Disease
- Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
- AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase.
- Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction.
- Interleukin-6, but not interleukin-4, is expressed by Reed-Sternberg cells in Hodgkin's disease with or without histologic features of Castleman's disease.
- Amyloid-associated amyloidosis in a HCV carrier with non-Hodgkin's lymphoma who had been treated with autologous stem cell transplantation and rituximab
- Burn-induced Oxidative Stress is Altered by a Low Zinc Status: Kinetic Study in Burned Rats Fed a Low Zinc Diet
- Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis
- Factores de risco na insuficiência renal crónica: estudo de factores genéticos e bioquímicos que possam contribuir para a patologia: relações com os sistemas de defesa antioxidante e imunitário
- Does a laparoscopic approach attenuate the body weight loss and lean body mass loss observed in open distal gastrectomy for gastric cancer? a single-institution exploratory analysis of the JCOG 0912 phase III trial
- Multiple reaction monitoring mass spectrometry to identify novel plasma protein biomarkers of treatment response in cystic fibrosis pulmonary exacerbations.
- Regulatory effects of interleukin-6 in immunoglobulin G immune-complex-induced lung injury.
- Influence of Serum from Rats with Fulminant Hepatic Failure on Hepatocytes in a Bioartificial Liver System
- Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia.
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