The Levels of Tau Isoforms Containing Exon-2 and Exon-10 Segments Increased in the Cerebrospinal Fluids of the Patients with Sporadic Creutzfeldt-Jakob Disease
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Summary
The data here propose the tau isoforms with exon-2 andExon-10 segments increase in CSF of sCJD and some types of gCJD, which may help to understand the physiological metabolism and pathological significance of various t Tau isoforms in the pathogenesis of prion diseases.
- Type
- article
- Published
- 2015-07-19
- Cited by
- 7
- References
- 37
- OpenAlex
- https://openalex.org/W890495913
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1822948
Keywords
Exon, Gene isoform, Scrapie, Cerebrospinal fluid, Biology
References
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- Clinical and differential diagnosis of Creutzfeldt-Jakob disease.
- Clinical and familial characteristics of ten chinese patients with fatal family insomnia.
- Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.
- Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD
- Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.
- Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy
- Tau protein isoforms, phosphorylation and role in neurodegenerative disorders.
- Preparation of human tau exon-2- and -10-specific monoclonal antibodies for the recognition of brain tau proteins in various mammals.
- Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt–Jakob disease
- Sporadic Pick's disease: A tauopathy characterized by a spectrum of pathological τ isoforms in gray and white matter
- Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt–Jakob disease
- Unexpected abundance of pathological tau in progressive supranuclear palsy white matter
- Human Prion disease with a T188K mutation in Chinese: a case report
- Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
- Use of 14–3–3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease
- Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies
- The first Chinese case of Creutzfeldt-Jakob disease with mutation of E200K in PRNP.
- Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system.
- Clinical and familial characteristics of eight Chinese patients with T188K genetic Creutzfeldt-Jakob disease.
Cited by
- Low activity of complement in the cerebrospinal fluid of the patients with various prion diseases
- Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection
- Calmodulin level is significantly increased in the cerebrospinal fluid of patients with sporadic Creutzfeldt‐Jakob disease
- Human prion disease
- Establishment of a Special Platform for the Research of Prion and the Diagnosis of Human Prion Disease — China’s Studies
- Challenges and Revisions in Diagnostic Criteria: Advancing Early Detection of Prion Diseases
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