Abdominal aortic aneurysm: update on pathogenesis and medical treatments
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Summary
This Review discusses the latest findings and current theories on the pathogenesis of abdominal aortic aneurysm (AAA) and highlights potential medical therapies for AAA, summarizing previous, ongoing, and potential clinical trials of medical interventions for small AAAs.
- Type
- review
- Published
- 2018-10-10
- Cited by
- 677
- References
- 233
- OpenAlex
- https://openalex.org/W2901378137
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53427276
Keywords
Medicine, Abdominal aortic aneurysm, Clinical trial, Disease, Intensive care medicine
References
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- Surrogate Markers of Abdominal Aortic Aneurysm Progression
- Screening for abdominal aortic aneurysm: lessons from a population‐based study
- Treatment With Simvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Normal and Hypercholesterolemic Mice
- SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model
- Doxycycline for Stabilization of Abdominal Aortic Aneurysms
- Final 12‐year follow‐up of Surgery versus Surveillance in the UK Small Aneurysm Trial
- Medical treatment for small abdominal aortic aneurysms.
- Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease
- Aneurysmal Lesions of Patients with Abdominal Aortic Aneurysm Contain Clonally Expanded T Cells
- Thrombospondin-1 (TSP1) Contributes to the Development of Vascular Inflammation by Regulating Monocytic Cell Motility in Mouse Models of Abdominal Aortic Aneurysm
- Editor's Choice - Pharmaceutical Management of Small Abdominal Aortic Aneurysms: A Systematic Review of the Clinical Evidence.
- Biomechanical factors in the biology of aortic wall and aortic valve diseases
- Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms.
- Assessment of biomarkers and predictive model for short-term prospective abdominal aortic aneurysm growth-A pilot study.
- Adventitial Mast Cells Contribute to Pathogenesis in the Progression of Abdominal Aortic Aneurysm
- Bone marrow mesenchymal stem cells stabilize already-formed aortic aneurysms more efficiently than vascular smooth muscle cells in a rat model.
- Endovascular treatment of abdominal aortic aneurysms
- A longitudinal comparison of hemodynamics and intraluminal thrombus deposition in abdominal aortic aneurysms.
- Rupture rates of untreated large abdominal aortic aneurysms in patients unfit for elective repair.
Cited by
- The Role of a Selective P2Y6 Receptor Antagonist, MRS2578, on the Formation of Angiotensin II-Induced Abdominal Aortic Aneurysms
- Analysis of High-Risk Factors Associated with the Progression of Subaneurysmal Aorta to Abdominal Aortic Aneurysm in Rural Area in China
- Ablation and Inhibition of the Immunoproteasome Catalytic Subunit LMP7 Attenuate Experimental Abdominal Aortic Aneurysm Formation in Mice
- Pathobiology of cardiovascular diseases: an update.
- Lack of an effective drug therapy for abdominal aortic aneurysm
- Myeloid related protein 8/14 is a new candidate biomarker and therapeutic target for abdominal aortic aneurysm.
- Computational Fluid Dynamics Modeling of Hemodynamic Parameters in the Human Diseased Aorta: A Systematic Review
- Toward the Existence of a Sympathetic Neuroplasticity Adaptive Mechanism Influencing the Immune Response. A Hypothetical View—Part I
- Silencing of NONO inhibits abdominal aortic aneurysm in apolipoprotein E‐knockout mice via collagen deposition and inflammatory inhibition
- Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation
- Lipid management in people with peripheral artery disease.
- Identification of crucial genes in abdominal aortic aneurysm by WGCNA
- Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth.
- Highlight article: Discovery of crucial cytokines associated with abdominal aortic aneurysm formation by protein array analysis
- Development of an in vitro system for cardiovascular flow measurements and computational study of cerebral aneurysm hemodynamics
- Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm
- Linking obesity with abdominal aortic aneurysm development
- Deficiency of IgE protects mice from experimental abdominal aortic aneurysms
- LINC00473 inhibits vascular smooth muscle cell viability to promote aneurysm formation via miR-212-5p/BASP1 axis.
- Angiotensin II and leukocyte trafficking: New insights for an old vascular mediator. Role of redox-signaling pathways.
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