NF-κB signaling in inflammation
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Summary
This review will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-σB inhibition.
- Type
- article
- Published
- 2017-07-14
- Cited by
- 7,770
- References
- 148
- Access
- Open access
- OpenAlex
- https://openalex.org/W2735527928
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30405373
Keywords
Inflammation, Signal transduction, Medicine, Computational biology, Immunology
References
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- IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
- Janeway's immunobiology
- Noncanonical NF-κB Activation Mediates STAT3-stimulated IDO Upregulation in Myeloid-Derived Suppressor Cells in Breast Cancer
- A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
- The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.
- Inflammasomes: Mechanism of Action, Role in Disease, and Therapeutics
- Cutting Edge: TNFR-Associated Factor (TRAF) 6 Is Essential for MyD88-Dependent Pathway but Not Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-β (TRIF)-Dependent Pathway in TLR Signaling1
- NF-κB1 p105 regulates T-cell homeostasis and prevent chronic inflammation
- Mechanism of NLRP3 inflammasome activation
- Transgenic Inhibition of Astroglial NF-κB Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation
- Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
- I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis.
- Activation of nuclear factor κB in inflammatory bowel disease
- Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts
Cited by
- Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages
- In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer
- Pathogenesis of Alkali Injury-Induced Limbal Stem Cell Deficiency: A Literature Survey of Animal Models
- Maternal Prenatal Depression Predicts Infant Negative Affect via Maternal Inflammatory Cytokine Levels
- The amino analogue of &bgr;‐boswellic acid efficiently attenuates the release of pro‐inflammatory mediators than its parent compound through the suppression of NF‐&kgr;B/I&kgr;B&agr; signalling axis
- NLR-Dependent Regulation of Inflammation in Multiple Sclerosis
- Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer
- Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity
- Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory
- Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders
- Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease
- REDD‐1 aggravates endotoxin‐induced inflammation VIA atypical NF‐κB activation
- Correlation between mast cell-mediated allergic inflammation and length of perfluorinated compounds
- Rutin and rutin‐conjugated gold nanoparticles ameliorate collagen‐induced arthritis in rats through inhibition of NF‐&kgr;B and iNOS activation
- Inhibition of ubiquitin-activating enzyme protects against organ injury after intestinal ischemia-reperfusion.
- Ethyl Acetate Fraction from Persimmon (Diospyros kaki) Ameliorates Cerebral Neuronal Loss and Cognitive Deficit via the JNK/Akt Pathway in TMT-Induced Mice
- Immunobiochemical reconstruction of influenza lung infection - Melanoma skin cancer interactions
- Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest
- Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
- Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties.
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