Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts
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Summary
The Wnt and BMP signaling pathways have emerged as critical in the regulation of osteoblast function and the outcome for bone in rheumatic diseases, and these pathways have been implicated in both bone loss in RA and bone formation in AS.
- Type
- review
- Published
- 2016-08-01
- Cited by
- 96
- References
- 162
- OpenAlex
- https://openalex.org/W1908326960
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37102378
Keywords
Bone remodeling, Osteoclast, Bone remodeling period, Bone resorption, Medicine
References
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Cited by
- Cellular and molecular pathways of structural damage in rheumatoid arthritis
- Interferon-Gamma-Mediated Osteoimmunology
- Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
- Autoimmunity in 2015
- Arthritis and other proliferative joint diseases
- Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis
- Denosumab: targeting the RANKL pathway to treat rheumatoid arthritis
- Cytosolic and Endosomal DNA-Sensing Pathways Differentially Regulate Inflammatory Arthritis, Autoantibody Production, and Bone Remodeling: A Dissertation
- Differences in osteoclast activity between rheumatoid arthritis and ankylosing spondylitis
- Acquired C1 Inhibitor Deficiency.
- Autoimmunity in 2016
- The non-canonical NF-κB pathway in immunity and inflammation
- Osteoblast Role in Rheumatic Diseases
- NF-κB signaling in inflammation
- Hierarchical, imbalanced pro-inflammatory cytokine networks govern the pathogenesis of chronic arthropathies.
- Deduction of Novel Genes Potentially Involved in Osteoblasts of Rheumatoid Arthritis Using Next-Generation Sequencing and Bioinformatic Approaches
- Berberine Prevents Bone and Cartilage Destruction and Influences Cell Senescence in Experimental Arthritis
- Amentoflavone Inhibits Osteoclastogenesis and Wear Debris-Induced Osteolysis via Suppressing NF-κB and MAPKs Signaling Pathways
- TNF inhibitor treatment is associated with a lower risk of hand osteoarthritis progression in rheumatoid arthritis patients after 10 years
- Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized
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