Endocannabinoid Regulation of Reward and Reinforcement through Interaction with Dopamine and Endogenous Opioid Signaling
Explore this paper's citation graph
Summary
This review explores the interaction of eCBs and their receptors functionally interact with opioid systems within the NAc to support reward, most likely through augmenting DA release.
- Type
- review
- Published
- 2018-01-01
- Cited by
- 137
- References
- 181
- Access
- Open access
- OpenAlex
- https://openalex.org/W2728347168
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25270656
Keywords
Ventral tegmental area, Nucleus accumbens, Incentive salience, Endocannabinoid system, Reward system
References
- Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors
- Is the short-latency dopamine response too short to signal reward error?
- Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
- Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid.
- THE ENDOCANNABINOID SYSTEM MODULATES THE VALENCE OF THE EMOTION ASSOCIATED TO FOOD INGESTION
- Pharmacological modulation of the endocannabinoid signalling alters binge‐type eating behaviour in female rats
- Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys
- CB2: a cannabinoid receptor with an identity crisis
- DAMGO depresses inhibitory synaptic transmission via different downstream pathways of μ opioid receptors in ventral tegmental area and periaqueductal gray.
- Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
- Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
- Primary food reward and reward predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum
- The orphan receptor GPR55 is a novel cannabinoid receptor
- Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
- REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
- Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol
- Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.
- GABAB‐Receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra
- Influence of Phasic and Tonic Dopamine Release on Receptor Activation
- The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication.
Cited by
- Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use
- The dopamine motive system: implications for drug and food addiction
- Endogenous opioids in the nucleus accumbens promote approach to high-fat food in the absence of caloric need
- Detection of cyclooxygenase-2-derived oxygenation products of the endogenous cannabinoid 2-arachidonoylglycerol in mouse brain
- Neurobiology of Physical Exercise: Perspectives on Psychophysiological Effects and Opioidergic Neurotransmission
- Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addiction
- Endocannabinoid-Enhanced “Liking” in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals
- Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus
- Unravelling the role and mechanism of adipokine and gastrointestinal signals in animal models in the nonhomeostatic control of energy homeostasis: Implications for binge eating disorder
- Local mu-opioid receptor antagonism blunts evoked phasic dopamine release in the nucleus accumbens of rats
- Combined Δ9-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats
- The association between endogenous opioid function and morphine responsiveness: a moderating role for endocannabinoids?
- Influence of itopride and domperidone on gastric tone and on the perception of gastric distention in healthy subjects
- The role of stress in drug addiction. An integrative review.
- Effect of acute Δ9-tetrahydrocannabinol administration on subjective and metabolic hormone responses to food stimuli and food intake in healthy humans: a randomized, placebo-controlled study.
- Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats
- The pharmacological reduction of hippocampal neurogenesis attenuates the protective effects of cannabidiol on cocaine voluntary intake
- Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse
- Δ9-tetrahydrocannabinol Attenuates Oxycodone Self-Administration Under Extended Access Conditions
- Endocannabinoids Interact With the Dopaminergic System to Increase Sexual Motivation: Lessons From the Sexual Satiety Phenomenon
Related papers
- NEUROGENETIC IMPAIRMENTS OF BRAIN REWARD CIRCUITRY LINKS TO REWARD DEFICIENCY SYNDROME (RDS) AS EVIDENCED BY GENETIC ADDICTION RISK SCORE (GARS): A CASE STUDY
- ‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders
- Dopamine in the Brain: Hypothesizing Surfeit or Deficit Links to Reward and Addiction
- ‘Liking’ and ‘wanting’ in eating and food reward: Brain mechanisms and clinical implications
- Endocannabinoid signaling system and brain reward: emphasis on dopamine.
- The impact of glucagon-like peptide-1 on the brain-reward system and beyond
- Reward and its control by dynorphin peptides.
- The hormonal signature of energy deficit: Increasing the value of food reward.