Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol
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Summary
These findings provide the first direct evidence of altered brain levels of endocannabinoids, and of 2‐AG in particular, during fasting and feeding, and supports a role for endoc cannabinoidoids in the control of appetitive motivation.
- Type
- article
- Published
- 2002-06-01
- Cited by
- 806
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1963482720
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13070545
Keywords
Endocannabinoid system, Endocrinology, Internal medicine, Cannabinoid receptor, Forebrain
References
- Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory.
- Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function.
- The rat brain in stereotaxic coordinates: Authors: George Paxinos & Charles Watson Academic Press Australia, 1982 Softback, 154 pages (including 71 plates), 35.00 Aust $
- Leptin-regulated endocannabinoids are involved in maintaining food intake
- Evidence of a Functional Relationship between the Nucleus Accumbens Shell and Lateral Hypothalamus Subserving the Control of Feeding Behavior
- Leptin and the regulation of body weight in mammals
- Determination and characterization of a cannabinoid receptor in rat brain.
- Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
- Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.
- Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response.
- Critical role of the endogenous cannabinoid system in mouse pup suckling and growth.
- The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking.
- Observational analysis of feeding induced by Delta9-THC and anandamide.
- Effects of SR141716A on ethanol and sucrose self-administration.
- Dual action of naloxone on feeding revealed by behavioural analysis: separate effects on initiation and termination of eating.
- Analysis of anandamide, an endogenous cannabinoid substance, and of other natural N-acylethanolamines.
- The effects of cannabinoids on the brain.
- Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
- Feeding induced by blockade of AMPA and kainate receptors within the ventral striatum: a microinfusion mapping study.
- Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
Cited by
- The Effect of Endocannabinoid System on Energy Metabolism and Obesity
- Feeding disorders and obesity.
- Impact of dietary conjugated linoleic acid (CLA) onfatty acid metabolism and endocannabinoidbiosynthesis
- n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice.
- Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.
- Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
- Recent progress in cannabinoid research.
- Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa.
- Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss.
- GABAergic and Cortical and Subcortical Glutamatergic Axon Terminals Contain CB1 Cannabinoid Receptors in the Ventromedial Nucleus of the Hypothalamus
- Cannabinoid signalling regulates inflammation and energy balance: the importance of the brain-gut axis.
- Investigations of the endocannabinoid system in adipose tissue: effects of obesity/ weight loss and treatment options.
- Chronic THC during adolescence increases the vulnerability to stress-induced relapse to heroin seeking in adult rats.
- Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice
- α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility.
- Nutritional status‐dependent endocannabinoid signalling regulates the integration of rat visceral information
- Endocannabinoids: Effectors of glucocorticoid signaling.
- Lessons from nonmammalian species.
- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes.
- Cannabinoid receptors and cholecystokinin in feeding inhibition.
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