AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
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Summary
The recently solved crystal structure of AMPK has shed light both into how nucleotides activate AMPK but, importantly, also into the sites bound by small molecule activators, thus providing a path for improved drugs.
- Type
- review
- Published
- 2017-06-15
- Cited by
- 1,815
- References
- 106
- Access
- Open access
- OpenAlex
- https://openalex.org/W2625887862
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31716140
Keywords
AMPK, Biology, Regulator, Cell biology, Protein kinase A
References
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- AMP-activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma
- Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
- Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise regulated kinases and AMPK substrates
- AMP-activated Protein Kinase Phosphorylates and Desensitizes Smooth Muscle Myosin Light Chain Kinase*♦
- Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK
- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
- Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
- MECHANISM OF ACTION OF A-769662, A VALUABLE TOOL FOR ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor*
- A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation
- Metformin activates duodenal AMPK and a neuronal network to lower glucose production
- Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity.
- AMPK at the crossroads of circadian clocks and metabolism
- Desnutrin/ATGL is Regulated by AMPK and is Required for a Brown Adipose Phenotype
- Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase*
- Transcriptional coregulators: fine-tuning metabolism
- Coordinated regulation of AMPK activity by multiple elements in the α-subunit
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- The regulatory role and mechanism of exosomes in hepatic fibrosis
- Mitochondrial fusion, fission, and mitochondrial toxicity Submitted for consideration for the Special Issue of Toxicology on “Chemical Mitochondrial Toxicity”
- Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing
- Salt-inducible kinases in adipose tissue
- The emerging role of AMP‐activated protein kinase in cholestatic liver diseases
- Kaempferol induces autophagic cell death of hepatocellular carcinoma cells via activating AMPK signaling
- Metformin and berberine, two versatile drugs in treatment of common metabolic diseases
- Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells
- MAGEA6 promotes human glioma cell survival via targeting AMPKα1.
- Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles
- Sensing and responding to energetic stress: Evolution of the AMPK network.
- Cold acclimation causes fiber type-specific responses in glucose and fat metabolism in rat skeletal muscles
- AMPK: Sensing Glucose as well as Cellular Energy Status.
- How cellular ATP/ADP ratios and reactive oxygen species affect AMPK signalling
- CD36 mediates lipid accumulation in pancreatic beta cells under the duress of glucolipotoxic conditions: Novel roles of lysine deacetylases
- AMPK and Friends: Central Regulators of β Cell Biology.
- Inhibition of Adipocyte Differentiation by Anthocyanins Isolated from the Fruit of Vitis coignetiae Pulliat is Associated with the Activation of AMPK Signaling Pathway
- Exercise and Mitochondrial Dynamics: Keeping in Shape with ROS and AMPK
- B-Cell Metabolic Remodeling and Cancer.
- The role of AMPK/mTOR modulators in therapy of acute myeloid leukemia.
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