AMP-activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma
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Summary
The Hedgehog (Hh) pathway regulates cell differentiation and proliferation during development by controlling the Gli transcription factors, which leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency.
- Type
- article
- Published
- 2015-07-16
- Cited by
- 40
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1658670721
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:263434457
Keywords
AMPK, GLI1, Protein kinase A, Cell biology, Hedgehog signaling pathway
References
- The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma
- AMPK/SNF1 structure: a menage a trois of energy-sensing.
- Ion channel regulation by the Lkb1‐AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level
- Localization of the primary metabolic block produced by 2-deoxyglucose.
- Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase
- Bio-orthogonal affinity purification of direct kinase substrates.
- The Crosstalk of mTOR/S6K1 and Hedgehog pathways
- AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
- The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor*
- Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.
- Unraveling the therapeutic potential of the Hedgehog pathway in cancer
- Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase*
- Mitochondria and human preimplantation embryo development.
- The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish
- Gene expression profiling demonstrates a novel role for foetal fibrocytes and the umbilical vessels in human fetoplacental development
- Regulation of ion channels and transporters by AMP-activated kinase (AMPK)
- Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells
- AMPK - a nutrient and energy sensor that maintains energy homeostasis
- AMPK is a negative regulator of the Warburg Effect and suppresses tumor growth in vivo
- Structural basis for AMP binding to mammalian AMP-activated protein kinase
Cited by
- Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions
- Proteomics of Primary Cilia by Proximity Labeling
- AMPK: an energy-sensing pathway with multiple inputs and outputs
- Targeting the Hedgehog Pathway in Pediatric Medulloblastoma
- The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint
- Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway
- Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy
- Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons
- The CD24 surface antigen in neural development and disease.
- The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells
- AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
- Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1
- AMPK: guardian of metabolism and mitochondrial homeostasis
- Loss of AMPKα2 Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis
- Gli Proteins: Regulation in Development and Cancer
- ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
- Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
- Korean red ginseng formula attenuates non-alcoholic fatty liver disease in oleic acid-induced HepG2 cells and high-fat diet-induced rats
- Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells
- Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma
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