The bioenergetics of inflammation: insights into obesity and type 2 diabetes
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Summary
The purpose of this review is to explore the metabolic demands of different immune cell types, and identify the molecular switches that control immune cell metabolism and ultimately function, and to review the latest clinical techniques used to measure metabolic flux in primary leukocytes isolated from obese and T2DM patients.
- Type
- review
- Published
- 2017-04-12
- Cited by
- 52
- References
- 93
- OpenAlex
- https://openalex.org/W2607190242
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13780306
Keywords
Inflammation, Insulin resistance, Immune system, Type 2 diabetes, Type 2 Diabetes Mellitus
References
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- Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction
- Hypoxia-Inducible Factor (HIF) 1α Accumulation and HIF Target Gene Expression Are Impaired after Induction of Endotoxin Tolerance1
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- De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
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- The inflammation highway: metabolism accelerates inflammatory traffic in obesity
- A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
- Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood
- Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
- Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8+ T Cell Memory Development
- Association between circulating cytokine levels, diabetes and insulin resistance in a population‐based sample (CoLaus study)
- Gene-Specific Epigenetic Regulation in Serious Infections with Systemic Inflammation
- Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters
- Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway*
- Monocyte Chemoattractant Protein 1 (MCP-1) in Obesity and Diabetes
Cited by
- Immunometabolism, pregnancy, and nutrition
- TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?
- "Cyt/Nuc," a Customizable and Documenting ImageJ Macro for Evaluation of Protein Distributions Between Cytosol and Nucleus.
- Elevated Glucose Levels Preserve Glucose Uptake, Hyaluronan Production, and Low Glutamate Release Following Interleukin-1β Stimulation of Differentiated Chondrocytes
- N‐Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high‐fat diet‐fed mice
- Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice
- sFasL-mediated induction of neutrophil activation in patients with type 2 diabetes mellitus
- Circulating blood immunophenotyping and metabolite profiling in pulmonary vascular diseases
- Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes
- Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases
- Gut Microbiota and Overweight in 3-year Old Children
- Cardiovascular effects of flavonoids.
- Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
- MIF and insulin: Lifetime companions from common genesis to common pathogenesis.
- Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer
- Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes
- The oral microbiome profile and biomarker in Chinese type 2 diabetes mellitus patients
- Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance
- Identifying the Therapeutic Significance of Mesenchymal Stem Cells
- Sustaining Circulating Regulatory T Cell Subset Contributes to the Therapeutic Effect of Paroxetine on Mice With Diabetic Cardiomyopathy.
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