The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses
Explore this paper's citation graph
Summary
The findings add a new regulatory layer through which HSP90 uncouples phenotypic outcomes from individual genotypes, and may have facilitated the exaptation of ERVs as key modifiers of gene expression and morphological diversification.
- Type
- article
- Published
- 2017-01-30
- Cited by
- 66
- References
- 66
- OpenAlex
- https://openalex.org/W2582713575
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3899707
Keywords
Biology, Epigenetics, Hsp90, Endogenous retrovirus, Genetics
References
- Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance
- Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation
- Hsp90 as a capacitor for morphological evolution
- Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish
- Genome engineering using CRISPR-Cas9 system.
- The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome
- The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing.
- Transposable elements as genetic regulatory substrates in early development
- Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons
- Hsp90 as a capacitor of phenotypic variation
- HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse
- The evolutionary significance of cis-regulatory mutations
- The Cochaperone Shutdown Defines a Group of Biogenesis Factors Essential for All piRNA Populations in Drosophila
- Endogenous retroviruses: acquisition, amplification and taming of genome invaders.
- Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
- Methylation-dependent and -independent genomic targeting principles of the MBD protein family.
- A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.
- A pipeline for the generation of shRNA transgenic mice
- Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
- TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
Cited by
- Molecular genetics: Chaperone protein gets personal
- Epigenetic control of retrotransposons in adult tissues: implications for immune regulation.
- Revisiting the Relationship between Transposable Elements and the Eukaryotic Stress Response.
- Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate
- TRIM28 and the control of transposable elements in the brain.
- The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes
- Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
- Transposable elements: all mobile, all different, some stress responsive, some adaptive?
- Epigenetic control of variation and stochasticity in metabolic disease
- It’s not magic - Hsp90 and its effects on genetic and epigenetic variation
- HSP90 buffers newly induced mutations in massively mutated plant lines
- The impact of transposable elements in adaptive evolution
- Transposable Element Dysregulation in Systemic Lupus Erythematosus and Regulation by Histone Conformation and Hsp90
- Functional principles and regulation of molecular chaperones.
- DnaJ chaperones contribute to canalization.
- SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
- Epigenetic control of endogenous retroviruses and their immune recognition in differentiated human cells
- Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells
- Stress-driven transposable element de-repression dynamics in a fungal pathogen
- An HSP90-regulated reduced-eye phenotype in Tribolium shows fitness benefits and thus provides evidence for evolutionary capacitance
Related papers
- The Research Advancement of Heat Shock Protein 90 in Tumor Prevention and Therapy
- Heat Shock Protein 90 (Hsp90) Chaperone Complex : A Molecular Target for Enhancement of Thermosensitivity and Radiosensitivity
- Targeting HSP90 for cancer therapy
- Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis.
- Radicicol activates heat shock protein expression and cardioprotection in neonatal rat cardiomyocytes.
- HSP70 and HSP90 in neurodegenerative diseases
- Heat shock protein 90 (HSP90) and immune regulation
- [Changes in heat shock protein synthesis and thermotolerance of Arabidopsis thaliana seedlings as a result of inhibition of Hsp90 by geldanamycin].