The Cochaperone Shutdown Defines a Group of Biogenesis Factors Essential for All piRNA Populations in Drosophila
Explore this paper's citation graph
Summary
It is demonstrated that Shutdown is essential for both primary and secondary piRNA populations in Drosophila, and a unified model for piRNA biogenesis is proposed.
- Type
- article
- Published
- 2012-09-28
- Cited by
- 142
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013883400
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15347090
Keywords
Piwi-interacting RNA, Biology, Biogenesis, RasiRNA, Genetics
References
- The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila
- Cyclophilin 40 facilitates HSP90‐mediated RISC assembly in plants
- Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.
- Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine.
- A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
- The piRNA Pathway: Guardian of the Genome –A Fly’s Perspective
- Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.
- A genome-scale shRNA resource for transgenic RNAi in Drosophila
- Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons
- 3' end formation of PIWI-interacting RNAs in vitro.
- Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line.
- A broadly conserved pathway generates 3' UTR-directed primary piRNAs
- Separation of stem cell maintenance and transposon silencing functions of Piwi protein
- The Yb Body, a Major Site for Piwi-associated RNA Biogenesis and a Gateway for Piwi Expression and Transport to the Nucleus in Somatic Cells*
- In vitro assembly of plant RNA-induced silencing complexes facilitated by molecular chaperone HSP90.
- Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway
- Establishment of stable cell lines of Drosophila germ-line stem cells
- Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response.
- Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas.
- A direct role for Hsp90 in pre-RISC formation in Drosophila
Cited by
- Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster
- The piRNA pathway in Drosophila ovarian germ and somatic cells
- Transposon activity and control in the Drosophila melanogaster germline
- Piwi proteins and piRNAs step onto the systems biology stage
- piRNA Biogenesis and Transposon Silencing in Drosophila: A Dissertation
- A Novel Role of UAP56 in piRNA Mediated Transposon Silencing: A Dissertation
- RISC assembly: Coordination between small RNAs and Argonaute proteins.
- piRNA biogenesis in the germline: From transcription of piRNA genomic sources to piRNA maturation.
- Identification and characterization of novel components of the Drosophila piRNA pathway
- piRNA-Guided Transposon Cleavage Initiljates Zucchini-Dependent, Phased piRNA Production
- Untangling the Web: The Diverse Functions of the PIWI/piRNA Pathway
- Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb.
- piRNA-guided slicing specifies transcripts for Zucchini dependent, phased piRNA biogenesis
- Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline.
- MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells
- Slicing and Binding by Ago3 or Aub Trigger Piwi-bound piRNA Production by Distinct Mechanisms
- AGO3 Slicer activity regulates mitochondria–nuage localization of Armitage and piRNA amplification
- PIWI proteins and PIWI–interacting RNAs in the soma
- The Genetic Makeup of the Drosophila piRNA Pathway
- A transcriptome-wide RNAi screen in the Drosophila ovary reveals novel factors of the germline piRNA pathway
Related papers
- Developmentally Regulated piRNA Clusters Implicate MILI in Transposon Control
- Distinct and Collaborative Functions of Yb and Armitage in Transposon-Targeting piRNA Biogenesis.
- Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors
- Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline
- Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells
- Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
- Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.