Epigenetic control of retrotransposons in adult tissues: implications for immune regulation.
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Summary
Future insight into this topic may teach us how to reactivate or silence specific retrotransposon families, to promote anti-tumor immunity or dampen autoimmunity through epigenetic modulation.
- Type
- review
- Published
- 2017-08-01
- Cited by
- 10
- References
- 81
- Access
- Open access
- OpenAlex
- https://openalex.org/W2728415420
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206992854
Keywords
Retrotransposon, Biology, Epigenetics, Immune system, Innate immune system
References
- Coevolution of retroelements and tandem zinc finger genes.
- The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes
- Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin
- Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
- Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
- Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
- Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells
- Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells
- DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts
- Global and Stage Specific Patterns of Krüppel-Associated-Box Zinc Finger Protein Gene Expression in Murine Early Embryonic Cells
- The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses
- Citrullination of Histone H3 Interferes with HP1-Mediated Transcriptional Repression
- Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
- Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
- A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly
- Cyclic GMP-AMP Synthase is an Innate Immune Sensor of HIV and Other Retroviruses
- DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
- De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine
- Embryonic stem cells use ZFP809 to silence retroviral DNAs
- Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements
Cited by
- Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go!
- The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s
- Resurrection of endogenous retroviruses during aging reinforces senescence
- APOBECs orchestrate genomic and epigenomic editing across health and disease.
- Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response
- SETDB1: Progress and prospects in cancer treatment potential and inhibitor research.
- Genomic and Epidemiological Investigations Reveal Chromosomal Integration of the Acipenserid Herpesvirus 3 Genome in Lake Sturgeon Acipenser fulvescens
- Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression
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