Regulatory T cells in cancer immunotherapy
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Summary
It is hoped that combination of Treg-cell targeting with the activation of tumor-specific effector T cells will make the current cancer immunotherapy more effective.
- Type
- review
- Published
- 2016-12-20
- Cited by
- 1,878
- References
- 86
- Access
- Open access
- OpenAlex
- https://openalex.org/W2561926137
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:567275
Keywords
Biology, Effector, FOXP3, Immune system, Immunology
References
- Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer
- Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
- Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans
- CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies
- Clonal Deletion Prunes, but does not Eliminate Self-Specific αβ CD8+ T Lymphocytes
- Autosomal-dominant immune dysregulation syndrome in humans with CTLA4 mutations
- Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals
- Regulatory T cells in tumor immunity
- Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
- Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification
- T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.
- Deconstructing the peptide-MHC specificity of T cell recognition
- CTLA-4 blockade increases IFNγ-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
- Foxp3 occupancy and regulation of key target genes during T-cell stimulation
- T cell assays and MIATA: the essential minimum for maximum impact.
- CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients.
- Cancer immunotherapy: moving beyond current vaccines
- Prognostic significance of regulatory T cells in tumor
- CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.
- Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
Cited by
- Chimeric antigen receptors and bispecific antibodies to retarget T cells in pediatric oncology
- Immunotherapy of Childhood Sarcomas
- Tumour‐associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice
- Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma.
- Dual roles of IL-22 at ischemia-reperfusion injury and acute rejection stages of rat allograft liver transplantation
- The potential immune-eliciting cancer testis antigens in colorectal cancer.
- Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells
- ncRNA-mediated SOX4 overexpression correlates with unfavorable outcomes and immune infiltration in hepatocellular carcinoma
- Beyond Adjuvants: Immunomodulation strategies to enhance T cell immunity
- Etude de l’immunité anti-tumorale à long-terme induite par traitement par un anticorps anti-CD20 de souris porteuses de tumeur
- Type I interferons and T regulatory cells : effects on development, homeostasis and function
- Increased expression of immunosuppressive molecules on intratumoral and circulating regulatory T cells in non-small-cell lung cancer patients.
- Control of regulatory T cell migration, function and homeostasis
- Methionine Enkephalin (MENK) Inhibits tumor growth through regulating CD4+Foxp3+ Regulatory T cells (Tregs) in mice
- Suppression of T cell responses in the tumor microenvironment.
- Targeting Treg signaling for the treatment of autoimmune diseases
- The role of regulatory T cells in cancer immunology
- Alterations of immune cell subsets in relapsed, thymoma-associated minimal change disease: A case report.
- Therapeutic cancer vaccines.
- The Prognostic Value of Forkhead Box P3 Expression in Operable Breast Cancer: A Large-Scale Meta-Analysis
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