Immunotherapy of Childhood Sarcomas
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Summary
This review will focus on recent preclinical and clinical developments in targeted agents for pediatric sarcomas with emphasis on the immunobiology of immune checkpoints, immunoediting, tumor microenvironment, antibody engineering, cell engineering, and tumor vaccines.
- Type
- article
- Published
- 2015-08-07
- Cited by
- 67
- References
- 149
- Access
- Open access
- OpenAlex
- https://openalex.org/W26301204
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17350362
Keywords
Personality, Psychology, Social psychology
References
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- Chimeric antigen receptors and bispecific antibodies to retarget T cells in pediatric oncology
- Genetic basis for clinical response to CTLA-4 blockade.
- Implications for Cancer Therapy
- Phase 2 Trial of Cixutumumab in Children, Adolescents and Young Adults with Refractory Solid Tumors: A Report from the Children's Oncology Group
- The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas.
- Ganglioside GD2 as a Therapeutic Target for Antibody-Mediated Therapy in Osteosarcoma
- Natural killer cells for osteosarcoma.
- Going Back to Class I: MHC and Immunotherapies for Childhood Cancer
- Expression of HER2/erbB-2 correlates with survival in osteosarcoma.
- Principles and Practice of Pediatric Oncology
- IL-2, Regulatory T Cells, and Tolerance
- Ganglioside GD2 specific monoclonal antibody 3F8: a phase I study in patients with neuroblastoma and malignant melanoma.
- Safety and immunologic effects of IL-15 administration in nonhuman primates.
- Cancer‐germline gene expression in pediatric solid tumors using quantitative real‐time PCR
- Paradoxical roles of the immune system during cancer development
- Expression of disialogangliosides GD2 and GD3 on human soft tissue sarcomas
- A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.
- Immune responses to the 105AD7 human anti-idiotypic vaccine after intensive chemotherapy, for osteosarcoma
- Targeting insulin and insulin-like growth factor signalling in oncology.
Cited by
- Future Directions in the Treatment of Osteosarcoma
- Dendritic and mast cell involvement in the inflammatory response to primary malignant bone tumours
- T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities
- Novel insights and therapeutic interventions for pediatric osteosarcoma.
- Uterine sarcoma part III-Targeted therapy: The Taiwan Association of Gynecology (TAG) systematic review.
- Evaluation of CD146 as Target for Radioimmunotherapy against Osteosarcoma
- Early Lymphocyte Recovery and Outcome in Osteosarcoma
- Immune Therapy for Sarcomas.
- Targeting the PD-1 pathway in pediatric solid tumors and brain tumors
- Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo
- Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies
- Serum and Glucocorticoid Inducible Kinase 1-Sensitive Survival, Proliferation and Migration of Rhabdomyosarcoma Cells
- Association of anti-HER2 antibody with graphene oxide for curative treatment of osteosarcoma.
- GADD45β loss ablates innate immunosuppression in cancer
- Investigating the Immune Microenvironment in Osteosarcomas
- Treatment and outcome of adult-onset neuroblastoma
- Pediatric Cancer Immunotherapy: Opportunities and Challenges
- Immunotherapy for osteosarcoma: Where do we go from here?
- Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects
- Targeting strategies of liposomal subunit vaccine delivery systems to improve vaccine efficacy
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