Acsl4 Dictates Ferroptosis Sensitivity by Shaping Cellular Lipid Composition
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Summary
It is demonstrated that pharmacological targeting of Acsl4 with the antidiabetic compound class, thiazolidinediones, ameliorates tissue demise in a murine model of ferroptosis, suggesting that Acsl4 inhibition is a viable therapeutic approach to prevent ferroptosis-related diseases.
- Type
- article
- Published
- 2016-11-14
- Cited by
- 3,715
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2549188196
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19815328
Keywords
GPX4, Biology, Programmed cell death, Cell biology, Chemistry
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Cited by
- Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists
- Ferroptosis: The Greasy Side of Cell Death.
- Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids.
- Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury
- The mechanisms behind heatstroke-induced intestinal damage
- Ferroptosis: Oxidized PEs trigger death.
- Oxidized Arachidonic/Adrenic Phosphatidylethanolamines Navigate Cells to Ferroptosis
- Ferroptosis and cell death mechanisms in Parkinson's disease
- DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression
- HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells
- Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis.
- Characterization of ferroptosis in murine models of hemochromatosis
- Iron and ferroptosis: A still ill‐defined liaison
- Ferroptosis Inhibition: Mechanisms and Opportunities.
- Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells
- Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis
- Autophagy and Ferroptosis - What's the Connection?
- Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance.
- The in vivo evidence for regulated necrosis
- Ferroptosis: bug or feature?
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