Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury
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Summary
Investigation of the role of PI3K-mediated ferroptosis signaling induced by mild therapeutic hypothermia indicated that MTH may activate the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by MIRI.
- Type
- article
- Published
- 2024-09-30
- Cited by
- 9
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W39364741
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:273009822
Keywords
Intellectualization, Meaning (existential), Human capital, Human resources, Process (computing)
References
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- Ferroptosis: an iron-dependent form of nonapoptotic cell death.
- Expression of transient receptor potential melastatin 7 up-regulated in the early stage of renal ischemia-reperfusion.
- Cardioprotective effect of therapeutic hypothermia at 34°C against ischaemia/reperfusion injury mediated by PI3K and nitric oxide in a rat isolated heart model.
- Regional Heterogeneity of Myocardial Reperfusion Injury: Effect of Mild Hypothermia
- Electroacupuncture regulates TRPM7 expression through the trkA/PI3K pathway after cerebral ischemia-reperfusion in rats.
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- Temperature changes of > or = 1 degree C alter functional neurologic outcome and histopathology in a canine model of complete cerebral ischemia.
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- The small chill: mild hypothermia for cardioprotection?
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- Prior Hypothermia Attenuates Malignant Hyperthermia in Susceptible Swine
- A Pilot Study of Rapid Cooling by Cold Saline and Endovascular Cooling Before Reperfusion in Patients With ST-Elevation Myocardial Infarction
- Mild perioperative hypothermia.
- ATP-induced cardioprotection against myocardial ischemia/reperfusion injury is mediated through the RISK pathway
Cited by
- The interaction between ferroptosis and myocardial ischemia–reperfusion injury: molecular mechanisms and potential therapeutic targets
- Mild hypothermia regulates neuronal inflammation and oxidative stress through HSP70 to alleviate brachial plexus injury
- DNA methylation-predicted protein differences between Yakutian and Central Russian populations
- Shionone attenuates endoplasmic reticulum stress-associated ferroptosis in cardiomyocytes by reducing LCN2 and regulating PI3K/Akt signaling
- From calcium signaling to cardiovascular pharmacology: TRPM7 as a key mechanistic regulator and emerging pharmacological focus.
- Xanthenone Orchestrates the Renin–Angiotensin System/Ferroptosis Crosstalk: A Novel AT2R‐Dependent Strategy Against Lower Limb Transient Ischemia‐Induced Liver Injury
- Targeting antioxidant mechanisms in myocardial ischemia-reperfusion injury: A review of therapeutic strategies and clinical progress.
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