Dereplication of peptidic natural products through database search of mass spectra
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Summary
DEREPLICATOR is a new dereplication algorithm that enabled high-throughput PNP identification and that is compatible with large-scale mass spectrometry-based screening platforms for natural product discovery.
- Type
- article
- Published
- 2016-10-31
- Cited by
- 220
- References
- 61
- OpenAlex
- https://openalex.org/W2546443756
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:351099
Keywords
Natural product, Identification (biology), Drug discovery, Combinatorial chemistry, Tandem mass spectrometry
References
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- Molecular cartography of the human skin surface in 3D
- A new antibiotic kills pathogens without detectable resistance
- Automated Genome Mining of Ribosomal Peptide Natural Products
- MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus
- Protein identification by spectral networks analysis
- Revised structure of mycosubtilin, a peptidolipid antibiotic from Bacillus subtilis.
- Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis.
Cited by
- Extending compound identification for molecular network using the LipidXplorer database independent method: A proof of concept using glycoalkaloids from Solanum pseudoquina A. St.-Hil.
- Natural products: Mapping an amazing thicket.
- Significance estimation for large scale untargeted metabolomics annotations
- Mining prokaryotes for antimicrobial compounds: from diversity to function.
- Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?
- Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens
- The Future of Chemical Information Is Now
- Global chemical analysis of biology by mass spectrometry
- Synthetic multispecies microbial communities reveals shifts in secondary metabolism and facilitates cryptic natural product discovery
- Metabolic Fingerprints from the Human Oral Microbiome Reveal a Vast Knowledge Gap of Secreted Small Peptidic Molecules
- Intertidal marine sediment harbours Actinobacteria with promising bioactive and biosynthetic potential
- Assessing the Significance of Peptide Spectrum Match Scores
- Significance estimation for large scale metabolomics annotations by spectral matching
- Omics-based Natural Product Discovery and the Lexicon of Genome Mining
- Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries
- Recent development of computational resources for new antibiotics discovery.
- MetaRiPPquest: A Peptidogenomics Approach for the Discovery of Ribosomally Synthesized and Post-translationally Modified Peptides
- Metabolomics tools for the synthetic biology of natural products.
- From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites.
- Increased diversity of peptidic natural products revealed by modification-tolerant database search of mass spectra
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