The role of natural product chemistry in drug discovery.
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Summary
To continue to be competitive with other drug discovery methods, natural product research needs to continually improve the speed of the screening, isolation, and structure elucidation processes, as well addressing the suitability of screens for natural product extracts and dealing with issues involved with large-scale compound supply.
- Type
- review
- Published
- 2004-11-23
- Cited by
- 1,404
- References
- 28
- OpenAlex
- https://openalex.org/W2127597456
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8102435
Keywords
Natural product, Drug discovery, Product (mathematics), Natural (archaeology), Drug
References
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- Magic and medicine
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- The History of Penicillin Production
- Handbook of Drug Screening.
- Drug discovery today.
- Screening of Natural Products Extracts for the Presence of Phosphodiesterase Inhibitors Using Liquid Chromatography Coupled Online to Parallel Biochemical Detection and Chemical Characterization
- In Quest of Tomorrow's Medicines
- Protein-protein interactions.
- The History of Penicillin Production
- Methods in Molecular Biology
- Drugs
Cited by
- Toxic plants: a chemist's perspective.
- Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery.
- Exploiting new approaches for natural product drug discovery in the biotechnology industry.
- Transition Metal-Participated Synthesis and Utilization of N-containing Heterocycles: Exploring for Nitrogen Sources.
- Antiproliferative activity of Haematoxylum brasiletto H. Karst
- Methyl Angolensate from Callus of Indian Redwood Induces Cytotoxicity in Human Breast Cancer Cells
- Understanding multidrug resistance in gram-negative bacteria--A study of a drug efflux pump AcrB and a periplasmic chaperone SurA
- Amélioration du comportement biopharmaceutique de triterpènes naturels anticancéreux par synthèse de saponines mono- et bidesmosidiques
- Bioassay-guided isolation and characterisation of antifungal metabolites
- Identification of anti-HIV compounds in Helichrysum species (Asteraceae) by means of NMR-based metabolomic guided fractionation
- Natural products isolation in modern drug discovery programs.
- Elucidating the mode-of-action of compounds from metabolite profiling studies.
- Biodiversité, origine et évolution des Cunoniaceae : implications pour la conservation de la flore de Nouvelle-Calédonie
- Synthèse de composés polyspiranniques par oxydation phénolique - Synthèse totale des aculéatines et d'analogues antipaludiques
- Bioactivity of marine organism-derived natural products
- Estudi etnofarmacològic de la vall de Chazuta (Amazònia peruana).
- Cytotoxic activities of selected medicinal plants from Iran and phytochemical evaluation of the most potent extract
- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.
- Indigenous Salvia species : an investigation of their pharmacological activities and phytochemistry
- Turmeric, the golden spice: From traditional medicine to modern medicine
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