Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus
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Summary
The results suggest specific hippocampal impairments in glutamate and glutamine metabolism, without affecting mitochondrial oxidation of these substrates, in the db/db mouse.
- Type
- article
- Published
- 2017-06-14
- Cited by
- 31
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2626000720
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2600541
Keywords
Glutamine, Hippocampal formation, Glutamate receptor, Diabetes mellitus, Endocrinology
References
- The glutamate/GABA‐glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
- Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer’s Disease
- Dysfunctional TCA‐Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes
- Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice.
- Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents.
- Glucose Levels and Risk of Dementia
- Glutamate is Preferred over Glutamine for Intermediary Metabolism in Cultured Cerebellar Neurons
- Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders
- Metabolism of [U‐13C5]Glutamine in Cultured Astrocytes Studied by NMR Spectroscopy: First Evidence of Astrocytic Pyruvate Recycling
- The glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
- Effect of Oxidative Stress on the Uptake of GABA and Glutamate in Synaptosomes Isolated from Diabetic Rat Brain
- Effects of fasting and diabetes on some enzymes and transport of glutamate in cortex slices or synaptosomes from rat brain
- Glutamate synthesis has to be matched by its degradation – where do all the carbons go?
- Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes
- Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes
- Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies
- Functional Importance of the Astrocytic Glycogen-Shunt and Glycolysis for Maintenance of an Intact Intra/Extracellular Glutamate Gradient
- INSULIN RESISTANCE IS ASSOCIATED WITH ALZHEIMER-LIKE REDUCTIONS IN REGIONAL CEREBRAL GLUCOSE METABOLISM FOR COGNITIVELY NORMAL ADULTS WITH PRE-DIABETES OR EARLY TYPE 2 DIABETES
- Obesity and Type 2 Diabetes in Rats are Associated with Altered Brain Glycogen and Amino-Acid Homeostasis
- Lipid Metabolism and Membrane Composition Are Altered in the Brains of Type II Diabetic Mice
Cited by
- Ultrastructural Remodeling of the Neurovascular Unit in the Female Diabetic db/db Model—Part I: Astrocyte
- Empagliflozin Ameliorates Type 2 Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female db/db Mouse
- The energetic brain – A review from students to students
- A systems biology approach to cellular homeostasis, volume changes and regulation of metabolism
- Interaction of human IAPP and Aβ1-42 aggravated the AD-related pathology and impaired the cognition in mice.
- PRECLINICAL MODELS OF DISEASE AND MULTIMORBIDITY WITH FOCUS UPON CARDIOVASCULAR DISEASE AND DEMENTIA.
- Serum Metabolites as an Indicator of Developing Gestational Diabetes Mellitus Later in the Pregnancy: A Prospective Cohort of a Chinese Population
- Modulatory effects of photobiomodulation in the anterior cingulate cortex of diabetic rats
- Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration.
- Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
- Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus
- Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo
- Hypothyroidism and Diabetes-Related Dementia: Focused on Neuronal Dysfunction, Insulin Resistance, and Dyslipidemia
- Metabolomics and biochemical insights on the regulation of aging-related diabetes by a low-molecular-weight polysaccharide from green microalga Chlorella pyrenoidosa
- P38 initiates degeneration of midbrain GABAergic and glutamatergic neurons in diabetes models
- Divergent Cellular Energetics, Glutamate Metabolism, and Mitochondrial Function Between Human and Mouse Cerebral Cortex
- Glial Glutamine Homeostasis in Health and Disease
- Magnetic resonance spectroscopy and liquid chromatography-mass spectrometry metabolomics study may differentiate pre-eclampsia from gestational hypertension
- Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex
- A novel Alzheimer’s disease prognostic signature: identification and analysis of glutamine metabolism genes in immunogenicity and immunotherapy efficacy
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