Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy.
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Summary
This is the first direct demonstration of the expression of the GLT-1 protein in activated microglial cells, suggesting a neuroprotective role of microglia against glutamate excitotoxicity following nerve axotomy.
- Type
- article
- Published
- 2000-03-29
- Cited by
- 115
- References
- 38
- OpenAlex
- https://openalex.org/W1970900916
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34692945
Keywords
Axotomy, Glutamate receptor, Excitotoxicity, Microglia, Biology
References
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- The microglia/macrophage response in the neonatal rat facial nucleus following axotomy.
- Cloning and expression of a rat brain L-glutamate transporter
- Regional and cellular expression of glial (GLT1) and neuronal (EAAC1) glutamate transporter proteins in ovine fetal brain.
- Localization of neuronal and glial glutamate transporters.
- Induction of Urokinase‐Type Plasminogen Activator in Rat Facial Nucleus by Axotomy of the Facial Nerve
- Glutamate neurotoxicity and diseases of the nervous system.
- Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia.
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- Neurotrophins regulate the function of cultured microglia
- Identification of Elastase as a Secretory Protease from Cultured Rat Microglia
- Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons
- Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy.
- Expression of glutamate transporters in cultured glial cells.
Cited by
- Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury.
- P2X7 receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport
- Regulation der Exzitatorischen Aminosäure Transporter EAAT1, EAAT2, EAAT3 und EAAT5 durch die Serum- und Glukokortikoid-abhängige Kinase SGK und die Ubiquitinligase Nedd4-2
- Regulation of glutamate transporters in health and disease.
- Microglia in the Regenerating and Degenerating Central Nervous System
- The glutamatergic system as a target for neuropathic pain relief
- Protective autoimmunity: interferon‐γ enables microglia to remove glutamate without evoking inflammatory mediators
- Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions
- Stimulation of α7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia.
- Attenuation of neurological injury with early baicalein treatment following subarachnoid hemorrhage in rats.
- Neuroprotective Immunity: T Cell-Derived Glutamate Endows Astrocytes with a Neuroprotective Phenotype
- Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor.
- Regulated Expression of Sodium‐dependent Glutamate Transporters and Synthetase: a Neuroprotective Role for Activated Microglia and Macrophages in HIV Infection?
- Rosiglitazone Attenuates Cerebral Vasospasm and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage
- Post‐translational regulation of EAAT2 function by co‐expressed ubiquitin ligase Nedd4‐2 is impacted by SGK kinases
- Temporal Changes of Astrocyte Activation and Glutamate Transporter‐1 Expression in the Spinal Cord After Spinal Nerve Ligation‐Induced Neuropathic Pain
- Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia
- Modulation of the glutamatergic receptors (AMPA and NMDA) and of glutamate vesicular transporter 2 in the rat facial nucleus after axotomy.
- Decreased Expression of Glutamate Transporters in Astrocytes after Human Traumatic Brain Injury
- Increased expression and function of glutamate transporters in multiple sclerosis.
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