Future Directions in the Treatment of Osteosarcoma
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Summary
Rigorous preclinical investigations are potentially generating novel strategies for the treatment of osteosarcoma that will inform the next generation of clinical trials, with the opportunity to identify agents that will improve survival outcomes.
- Type
- review
- Published
- 2016-02-01
- Cited by
- 294
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W2346520135
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24799532
Keywords
Medicine, Osteosarcoma, Clinical trial, Disease, Bioinformatics
References
- Immunotherapy of Childhood Sarcomas
- Ganglioside GD2 as a Therapeutic Target for Antibody-Mediated Therapy in Osteosarcoma
- A Summary of the Osteosarcoma Banking Efforts: A Report from the Children’s Oncology Group and the QuadW Foundation
- Initial Testing (Stage 1) of Glembatumumab Vedotin (CDX-011) by the Pediatric Preclinical Testing Program
- Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma
- A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
- Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
- Rapid Protocol Enrollment in Osteosarcoma: a report from the Children’s Oncology Group
- A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma
- Aerosol Interleukin-2 Induces Natural Killer Cell Proliferation in the Lung and Combination Therapy Improves the Survival of Mice with Osteosarcoma Lung Metastasis
- Osteogenic sarcoma with clinically detectable metastasis at initial presentation.
- Towards a Drug Development Path that Targets Metastatic Progression in Osteosarcoma
- Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells
- Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
- Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program
- WEE1 inhibition sensitizes osteosarcoma to radiotherapy
- The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models
- Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma
- Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas
- Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer
Cited by
- Assessment of GSK1904529A as a promising anti-osteosarcoma agent
- The tumor suppressor miR-124 inhibits cell proliferation and invasion by targeting B7-H3 in osteosarcoma
- Novel insights and therapeutic interventions for pediatric osteosarcoma.
- Advances in the management of osteosarcoma
- Inhibiting DNA-PKCS Radiosensitizes Human Osteosarcoma Cells
- Osteogenic Sarcoma: Systemic Chemotherapy Options for Localized Disease
- Anti-proliferative, pro-apoptotic and anti-invasive effect of EC/EV system in human osteosarcoma
- Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition
- LncRNA FENDRR sensitizes doxorubicin-resistance of osteosarcoma cells through down-regulating ABCB1 and ABCC1
- TRIM28 is Overexpressed in Osteosarcoma and Associated with Tumor Progression
- Hypoxia promotes proliferation and invasion of osteosarcoma cell line SaOS-2 in vitro by activating Wnt/β-catenin signaling
- ABT-737 potentiates cisplatin-induced apoptosis in human osteosarcoma cells via the mitochondrial apoptotic pathway.
- Postoperative und posttherapeutische Veränderungen nach primären Knochentumoren
- miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14
- IMPROVING NK CELL THERAPY FOR OSTEOSARCOMA
- Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics
- miRNA profiling identifies deregulated miRNAs associated with osteosarcoma development and time to metastasis in two large cohorts
- SphK2 over-expression promotes osteosarcoma cell growth
- CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model
- Current and future therapeutic approaches for osteosarcoma
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