Novel insights and therapeutic interventions for pediatric osteosarcoma.
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Summary
Novel insights are described into the genomics, biology and immunology of the disease and selected strategies hold promise to overcome the current stagnation in the therapeutic success in childhood osteosarcoma.
- Type
- review
- Published
- 2017-02-01
- Cited by
- 218
- References
- 85
- OpenAlex
- https://openalex.org/W2522803584
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45457065
Keywords
Medicine, Osteosarcoma, Disease, Psychological intervention, Chemotherapy
References
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- Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma
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- Temsirolimus combined with cisplatin or bevacizumab is active in osteosarcoma models
- Pharmacogenomics in the clinic
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- Phase 1 Clinical Trial of Ipilimumab In Pediatric Patients With Advanced Solid Tumors
- An update on chemotherapy for osteosarcoma
- Engineering anti‐GD2 monoclonal antibodies for cancer immunotherapy
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Cited by
- Managing sarcoma: where have we come from and where are we going?
- Ominous Trends in Childhood Cancer Mortality: Who was Right?
- Postoperative und posttherapeutische Veränderungen nach primären Knochentumoren
- Detection of circulating tumor DNA in patients with osteosarcoma
- Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents.
- Eggshell derived Se-doped HA nanorods for enhanced antitumor effect and curcumin delivery
- Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
- MicroRNA‐221 regulates osteosarcoma cell proliferation, apoptosis, migration, and invasion by targeting CDKN1B/p27
- Are Regulatory Age Limits in Pediatric Melanoma Justified?
- Screening of a growth inhibitor library of sarcoma cell lines to identify potent anti-cancer drugs
- LncRNA THOR increases osteosarcoma cell stemness and migration by enhancing SOX9 mRNA stability
- Prognostic Significance of Programmed Death Ligand 1 Expression and Tumor-Infiltrating Lymphocytes in Axial Osteosarcoma.
- RETRACTED ARTICLE: Long non-coding RNA CCAT2 acts as an oncogene in osteosarcoma through regulation of miR-200b/VEGF
- miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma
- An update on emerging drugs in osteosarcoma: towards tailored therapies?
- LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis
- Emerging Anticancer Potentials of Selenium on Osteosarcoma
- LncRNA DANCR silence inhibits SOX5-medicated progression and autophagy in osteosarcoma via regulating miR-216a-5p.
- The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model
- MicroRNA-1269a promotes the occurrence and progression of osteosarcoma by inhibit-ing TGF-β1 expression.
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