Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
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Summary
The cellular ecosystem of tumors is begin to unravel and how single-cell genomics offers insights with implications for both targeted and immune therapies is unraveled.
- Type
- article
- Published
- 2016-04-01
- Cited by
- 4,450
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W2332292689
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206641694
Keywords
Microphthalmia-associated transcription factor, Biology, Melanoma, Single-cell analysis, Stromal cell
References
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- Preparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
- Inhibitory Receptors Beyond T Cell Exhaustion
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
- Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance
- Genomic Classification of Cutaneous Melanoma
- Phenotype Switching in Melanoma: Implications for Progression and Therapy
- Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients.
- Activation of the AXL Kinase Causes Resistance to EGFR-Targeted Therapy in Lung Cancer
- Tumour heterogeneity and cancer cell plasticity
- RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
- A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
- Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
- Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
- Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.
- Common markers of proliferation
- The transcription factor NFAT promotes exhaustion of activated CD8+ T cells
- Smart-seq2 for sensitive full-length transcriptome profiling in single cells
- New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).
Cited by
- Resident Breast T-cells: The Troops Are Already There
- Exosomes in the tumor microenvironment as mediators of cancer therapy resistance
- Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment
- Tumor-associated myeloid cells: diversity and therapeutic targeting
- Genomic Applications in Pathology
- Disease Gene Identification
- Convergent Science Physical Oncology
- Comparative Analysis of Single-Cell RNA Sequencing Methods
- Congrès de l’association américaine de recherche contre le cancer — AACR 2016
- Molecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies
- High Throughput Genomic Profiling of Tumor-Infiltrating Leukocytes
- Bidirectional cross talk between patient‐derived melanoma and cancer‐associated fibroblasts promotes invasion and proliferation
- A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells
- Massively parallel digital transcriptional profiling of single cells
- Precision medicine, genomics and drug discovery.
- Overcome Tumor Heterogeneity-Imposed Therapeutic Barriers through Convergent Genomic Biomarker Discovery: A Braided Cancer River Model of Kidney Cancer
- Divide or Conquer: Cell cycle regulation of invasive behavior
- Single-Cell Transcriptomics Bioinformatics and Computational Challenges
- Genomic Approaches to Understanding Response and Resistance to Immunotherapy
- Writ large: Genomic Dissection of the Effect of Cellular Environment on Immune Response
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