Chronic heart failure: Ca2+, catabolism, and catastrophic cell death
Explore this paper's citation graph
Summary
Fundamental mechanisms of heart failure are reviewed, both with reduced (HFrEF) and preserved (HFpEF) ejection fraction, and pathways that regulate cardiomyocyte remodeling and turnover are discussed, focusing on Ca2+ signaling, autophagy, and apoptosis.
- Type
- review
- Published
- 2016-01-13
- Cited by
- 37
- References
- 309
- Access
- Open access
- OpenAlex
- https://openalex.org/W2232883894
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20775792
Keywords
Heart failure, Autophagy, Disease, Medicine, Heart disease
References
- Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a.
- A synopsis of research in cardiac apoptosis and its application to congestive heart failure.
- Alternative functions of the BCL-2 protein family at the endoplasmic reticulum.
- Design of a phase 2b trial of intracoronary administration of AAV1/SERCA2a in patients with advanced heart failure: the CUPID 2 trial (calcium up-regulation by percutaneous administration of gene therapy in cardiac disease phase 2b).
- RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study.
- [Protein kinases in mitochondria].
- Mitochondria and heart disease.
- Spliced XBP1 promotes macrophage survival and autophagy by interacting with Beclin-1.
- Angiotensin receptor blockers: Focus on cardiac and renal injury.
- Muscle : fundamental biology and mechanisms of disease
- The alpha1-adrenergic receptors in cardiac hypertrophy: signaling mechanisms and functional implications.
- Calcium signalling: dynamics, homeostasis and remodelling
- Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications
- Acute decompensated heart failure: contemporary medical management.
- The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury
- Chronic inhibition of cGMP‐specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure
- Na+/Ca2+ exchange and Na+/K+-ATPase in the heart
- Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function
- Polycystins and partners: proposed role in mechanosensitivity
- MicroRNA‐214 Is Upregulated in Heart Failure Patients and Suppresses XBP1‐Mediated Endothelial Cells Angiogenesis
Cited by
- Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model
- CaMKII: The molecular villain that aggravates cardiovascular disease
- The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training
- SERCA Control of Cell Death and Survival
- A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban
- Plasma cBIN1 Score (CS) Identifies HFpEF and Can Predict Cardiac Hospitalization in Stable Ambulatory Patients
- Raf kinase inhibitor protein: lessons of a better way for β‐adrenergic receptor activation in the heart
- Peptide-functionalized carbon dots for sensitive and selective Ca2+ detection
- Negative chronotropism, positive inotropism and lusitropism of 3,5‐di‐t‐butyl‐4‐hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak
- Targeting RyR2 with a phosphorylation site–specific nanobody reverses dysfunction of failing cardiomyocytes in rats
- Assessment of PKA and PKC Inhibitors on Force and Kinetics of Non-failing and Failing Human Myocardium
- Targeting RyR2 with a phosphorylation site-specific nanobody Reverses Dysfunction of Failing Cardiomyocytes in Rat
- Acoustic and afterload evaluation of left ventricular assist devices
- Genome-wide translational reprogramming of genes important for myocyte functions in overload-induced heart failure.
- Chronic cardiac structural damage, diastolic and systolic dysfunction following acute myocardial injury due to bromine exposure in rats
- The dawn of the four-drug era? SGLT2 inhibition in heart failure with reduced ejection fraction
- Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury
- Integration of network pharmacology and molecular docking technology reveals the mechanism of the herbal pairing of Codonopsis Pilosula (Franch.) Nannf and Astragalus Membranaceus (Fisch.) Bge on chronic heart failure.
- Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway
- Heart Failure And Type 2 Diabetes Mellitus: Neurohumoral, Histological And Molecular Interconnections
Related papers
- Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy
- There is more to autophagy than induction
- Roles of autophagy in lymphocytes: reflections and directions
- Autophagy and cardiovascular diseases
- Autophagic pathways as new targets for cancer drug development
- Defining heart failure in adult congenital heart disease