Raf kinase inhibitor protein: lessons of a better way for β‐adrenergic receptor activation in the heart
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Summary
The current knowledge on RKIP‐driven compared to receptor‐mediated signalling in cardiomyocytes is summarized and emphasis is given to the differential effects of RkIP on β1‐ and β2‐ARs and their downstream targets, the regulation of myocyte calcium cycling and myofilament activity.
- Type
- review
- Published
- 2017-04-01
- Cited by
- 22
- References
- 126
- Access
- Open access
- OpenAlex
- https://openalex.org/W2883144558
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3995000
Keywords
Protein kinase A, Beta adrenergic receptor kinase, Adrenergic receptor, Chemistry, Adrenergic
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Cited by
- Calcium Ions in Inherited Cardiomyopathies.
- Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome
- The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.
- Dose-Dependent Effects of Long-Term Administration of Hydrogen Sulfide on Myocardial Ischemia–Reperfusion Injury in Male Wistar Rats: Modulation of RKIP, NF-κB, and Oxidative Stress
- Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease
- Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies
- Insights of RKIP-Derived Suppression of Prostate Cancer
- Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload
- Harnessing RKIP to Combat Heart Disease and Cancer
- RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression.
- From "contraindicated" to "first line" - Current mechanistic insights beyond canonical β-receptor signaling.
- Remodeling of T-Tubules and Associated Calcium Handling Dysfunction in Heart Failure: Mechanisms and Therapeutic Insights.
- Trametinib alters contractility of paediatric Noonan syndrome‐associated hypertrophic myocardial tissue slices
- From Ca2+ dysregulation to heart failure: β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLNR9C by correction of aberrant Ca2+-handling.
- RASopathies and Cardiac Complications: Insights into Mechanisms, Diagnosis, and Innovative Treatments
- PKA Restricts ERK Signaling in Learning and Memory Kenyon Cell Neurons
- Protein Kinase A Phosphorylates a Conformationally High-Energy State of Raf Kinase Inhibitory Protein
- Cardiac regulatory mechanisms: new concepts and challenges
- Alterations in the Sympathetic and Parasympathetic Nervous Systems in Heart Failure
- Molecular insights driving personalized therapies.
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