Lipotoxicity disrupts incretin-regulated human β cell connectivity.
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Summary
It is demonstrated that β cell connectedness is an inherent property of human islets that is likely to influence incretin-potentiated insulin secretion and may be perturbed by diabetogenic insults to disrupt glucose homeostasis in humans.
- Type
- article
- Published
- 2013-10-01
- Cited by
- 218
- References
- 85
- Access
- Open access
- OpenAlex
- https://openalex.org/W2065285024
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13330651
Keywords
Incretin, Lipotoxicity, Internal medicine, Glucose homeostasis, Endocrinology
References
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- Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β‐cells
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- Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women’s Health Study
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Cited by
- Type 2 diabetes mellitus
- Multilayer network representation of membrane potential and cytosolic calcium concentration dynamics in beta cells
- The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans
- The past 10 years—new hormones, new functions, new endocrine organs
- Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans
- The relationship between node degree and dissipation rate in networks of diffusively coupled oscillators and its significance for pancreatic beta cells.
- Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?
- Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis
- Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects
- The effect of fermentable carbohydrate on glucose homeostasis and weight management in people at high-risk of developing diabetes
- Optical Control of Insulin Secretion Using an Incretin Switch
- Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells
- Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter
- Glucolipotoxicité dans les cellules bêta pancréatiques
- Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretion
- Incretin action on bone: An added benefit?
- New insights into the role of connexins in pancreatic islet function and diabetes
- Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability
- JNK3 Is Required for the Cytoprotective Effect of Exendin 4
- Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells
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