The role of inflammation in depression: from evolutionary imperative to modern treatment target
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Summary
Current understanding of the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression are detailed.
- Type
- review
- Published
- 2015-12-29
- Cited by
- 3,537
- References
- 144
- Access
- Open access
- OpenAlex
- https://openalex.org/W2201607793
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9103431
Keywords
Neuroscience, Immune system, Inflammation, Antidepressant, Crosstalk
References
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Cited by
- Autoimmunity, neuroinflammation, pathogen load: A decisive crosstalk in neuropsychiatric SLE.
- Biomarkers for depression: recent insights, current challenges and future prospects
- Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation
- Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists
- P2X7 Receptor: A Potential Therapeutic Target for Depression?
- Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice
- The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice.
- Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats
- Hidden Wounds? Inflammatory Links Between Childhood Trauma and Psychopathology
- Mastocytosis in adulthood and neuropsychiatric disorders.
- Agomelatine’s effect on human genetic material: in vitro study
- Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder
- Depression Phenotype, Inflammation, and the Brain: Implications for Future Research.
- Expression and Function of Inflammation-Associated MicroRNAs in Traumatic Brain Injury
- The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice
- Inflammatory insults and mental health consequences: does timing matter when it comes to depression?
- Integrating neuroimmune systems in the neurobiology of depression
- The Promise and Limitations of Anti-Inflammatory Agents for the Treatment of Major Depressive Disorder.
- Inflammation and the microbiome: implications for depressive disorders.
- Well-being and immune response: a multi-system perspective.
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