P2X7 Receptor: A Potential Therapeutic Target for Depression?
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Summary
It is proposed that P2X7R is a putative target with good prospects for therapeutic intervention in depressive disorders and Gln460Arg missense mutation is validated as a potential genetic risk factor.
- Type
- article
- Published
- 2018-09-01
- Cited by
- 86
- References
- 96
- Access
- Open access
- OpenAlex
- https://openalex.org/W30093269
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:51952986
Keywords
Medicine
References
- Two haplotypes of the P2X7 receptor containing the Ala‐348 to Thr polymorphism exhibit a gain‐of‐function effect and enhanced interleukin‐1β secretion
- Regulation of innate immunity by extracellular nucleotides.
- Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohn's Disease: A Randomized Placebo-controlled, Double-blind, Phase IIa Study
- Neuroimmune mechanisms of depression
- Wake and sleep EEG provide biomarkers in depression.
- P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts
- A meta-analysis of cytokines in major depression.
- Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures
- Astrocyte-Mediated Ischemic Tolerance
- Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms.
- The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System
- Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test.
- P2RX7: Expression Responds to Sleep Deprivation and Associates with Rapid Cycling in Bipolar Disorder Type 1
- Gene–Environment Interactions in Severe Mental Illness
- Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder
- Lymphocytes from P2X7‐deficient mice exhibit enhanced P2X7 responses
- Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: a cumulative threshold spectra analysis.
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12
- Genetic Architectures of Psychiatric Disorders: The Emerging Picture and Its Implications
- Rapid eye movement (REM) sleep: An endophenotype for depression
Cited by
- Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease
- Regulation of P2X7 receptor expression and function in the brain.
- Mitochondria, Microglia, and the Immune System—How Are They Linked in Affective Disorders?
- Association of purinergic receptor P2RX7 gene polymorphisms with depression symptoms
- The P2X7 receptor: a new therapeutic target in Alzheimer’s disease
- P2X7 Receptor Signaling in Stress and Depression
- Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor
- miR-124 ameliorates depressive-like behavior by targeting STAT3 to regulate microglial activation.
- P2X7 receptor knockout mice display less aggressive biting behaviour correlating with increased brain activation in the piriform cortex.
- Acute Microglial Responses to Single Non-Epileptogenic vs. Epileptogenic Seizures in Mouse Hippocampus
- Effects of Adjunctive Inflammatory Modulation on IL-1β in Treatment Resistant Bipolar Depression.
- Pathological ATPergic Signaling in Major Depression and Bipolar Disorder
- The pharmacological properties of chrysophanol, the recent advances.
- To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?
- Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications
- Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge
- P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases
- FTY720 in CNS injuries: Molecular Mechanisms and Therapeutic Potential.
- Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease
- Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model
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